P53 marker expression in epithelial ovarian tumours in a centre in Nigeria - a descriptive study.

Background: p53 is a tumor suppressor gene. p53 expression in epithelial ovarian tumors (EOTs) is correlated with their biological behavior and predicts patient overall survival. However, there is a dearth of knowledge regarding p53 expression in these tumors among women from southwest Nigeria.

Immediate lymph node extraction improves retrieval rate following axillary lymph node dissection: an effective approach to improving guideline-concordant breast cancer care in Nigeria.

Background: Axillary lymph node staging is essential for making therapeutic decisions and for prognostication. A minimum of ten lymph nodes is recommended for accurate staging. This study describes the process and outcomes of an audit cycle that resulted in a novel intervention instituted to improve concordance with guidelines.

Medical and Dental Students' Perceptions of the Learning Environment during Anatomic Pathology Placement at Obafemi Awolowo University, Ile-Ife, Nigeria.

Background: The educational environment is an important factor in nurturing students' learning. Students' experiences of the climate of their learning environment positively correlate with their academic success, achievements and satisfaction.

Objectives: The study aimed to determine the perceptions of medical and dental students about their learning environment during anatomical pathology clinical placement.

Comparative Immunohistochemical Analysis of p53 and Alpha-SMA in Ameloblastoma, AOT and OKC.

Objectives: Ameloblastoma is a benign but highly infiltrative tumour, a behaviour that is lacking in adenomatoid odontogenic tumour but partly shared by the odontogenic keratocyst which possesses a unique intrinsic growth potential with marked ability for destroying bone and a high tendency recurrence. High frequency of stromal myofibroblasts (assessed with alpha smooth muscle actin (α-SMA) correlates with aggressive behaviour while p53-cell cycle regulation system is critical in odontogenic tumours with immunoreactivity signifying prognostic status. This study aims to determine and compare the immunoreactivity of these selected tumours to p53 and α-SMA in order to establish if a relationship exists between the frequency and pattern of distribution of myofibroblasts and the behaviour of these lesions.

Contemporary management of breast cancer in Nigeria: Insights from an institutional database.

High-quality data are needed to guide interventions aimed at improving breast cancer outcomes in sub-Saharan Africa. We present data from an institutional breast cancer database to create a framework for cancer policy and development in Nigeria. An institutional database was queried for consecutive patients diagnosed with breast cancer between January 2010 and December 2018.

Learners' Perception of the Applicability of Pre-clinical Subjects to Clinical Training and Experience in Obafemi Awolowo University, Ile-Ife.

This article was migrated. The article was marked as recommended. This study investigated how Final Year Students and Newly qualified Doctors of Obafemi Awolowo University (OAU) Medical School perceive the applicability of the three pre-clinical subjects (Anatomy, Biochemistry and Physiology) to clinical studies and medical practice with the aim of ascertaining whether or not the students are able to establish a real connect between knowledge acquired in the pre-clinical years and their experience during clinical exposure.

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities.

Introduction: Breast cancer outcomes vary across different ethnic groups. MicroRNAs (miRs) are small non-coding RNA molecules that regulate gene expression across a range of pathologies, including breast cancer. The aim of this study was to evaluate the presence and expression of miRs in breast cancer samples from different ethnic groups.

Age and Pattern of Pap Smear Abnormalities: Implications for Cervical Cancer Control in a Developing Country.

Aim: To characterize the age and pattern of Pap smear abnormalities in a major teaching hospital in Southwestern Nigeria.

Design: This is a review of medical records of patients that came for cervical cancer screening.

Materials And Methods: The Pap smear results of women between May 2013 and April 2015 were retrieved.

Metal uptake, oxidative stress and histopathological alterations in gills and hepatopancreas of Callinectes amnicola exposed to industrial effluent.

Metal uptake by biota due to elevated environmental concentrations elicits oxidative stress and could lead to pathological outcomes. The relationship between the histopathological profile of hepatopancreas and gills and altered biochemical features (antioxidant enzymes i.e.

Clinical correlates of leiomyoma estrogen and progesterone receptors among Nigerian women.

Objective: To compare the expression of estrogen receptor α (ERα) and progesterone receptor (PR) in myometrium and leiomyomata tissue, and to correlate their expression with symptoms of uterine leiomyomata.

Methods: In a cross-sectional study, intraoperative biopsy samples of leiomyomata and adjacent myometrial specimens were obtained from premenopausal women with uterine leiomyomata treated at a center in Nigeria between September 2013 and August 2014. Immunohistochemistry for ERα and PR expression was performed on the samples.

Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype.

Introduction: Little is known about the biology, molecular profile and hence optimal treatment of African Nigerian breast cancer. The aim of this work, therefore, was to characterize the histology and molecular profile of Nigerian breast cancer.

Methods: Breast carcinomas from women at 6 centres of similar tribal origin in Nigeria were reviewed and assembled into tissue microarrays (TMAs), and sections were stained for hormone receptors, i.

Carcinoma head of the pancreas masquerading as hepatocellular carcinoma: a case report.

Background: Cancer of the pancreas is the primary malignant tumour of the pancreas commonly seen in the elderly. Hepatitis B virus infection is not a known marker of the disease, but patient with carcinoma head of the pancreas presenting with epigastric mass with positive hepatitis B infection in the region of the world with high endemicity for hepatitis B virus infection may cause diagnostic pitfall.

Objective: To present a case of carcinoma head of the pancreas masqueradingas hepatocellular carcinoma

Methods: A review of the case note, autopsy findings including gross and microscopic examinations and literature was done.

Human cysticercosis of the breast mimicking breast cancer: a report of a case from Ile-Ife, Nigeria.

Background: Human cystericosis is the infection caused by the larvae of pork tapeworm Taeniasolium. The infection commonly affects the muscle, the central nervous system and subcutaneous tissues. The involvement of the breast is unusual.

Perinatal autopsies in a tertiary health facility in Southwestern Nigeria: a retrospective evaluation of 14 consecutive cases.

Background: Perinatal autopsy remains a valuable tool in perinatal medicine. It provides an insight into the genetic implications of subsequent pregnancies and also helps reduce parental events such as maternal illness or maternal use of medications. The practice is not popularly acceptable in our environment for socio-cultural reasons.

Pattern of placenta histopathology in low birth weight babies seen in a tertiary health centre in South-Western Nigeria.

Background: Pre-term delivery is usually associated with low birth weight and is a known obstectrics problem in our setting. Few Histopathologists are interested in placental pathology, and this is particularly so because consent is often difficult to get from the relatives making few specimens available for study in our environment.

Objective: Our objective was to evaluate the placental histopathology in low birth weight infants (LBW, birth weight < 2500 g) and to determine if placental histopathological findings are associated with low birth weight and preterm deliveries.

Autopsy-certified maternal mortality at Ile-Ife, Nigeria.

Aim: Maternal mortality is a major health problem, especially in Nigeria, where accurate autopsy-based data on the prevalent causes are not readily available. The aim of this study was therefore to accurately determine the causes of maternal death as seen in a tertiary health facility in Nigeria.

Materials And Methods: This was a descriptive, retrospective review of the postmortem autopsy findings from cases of maternal death at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria over a 5-year period.

A huge low-grade fibromyxoid sarcoma of small bowel mesentery simulating hyper immune splenomegaly syndrome: a case report and review of literature.

Introduction: Low-grade fibromyxoid sarcoma (LGFMS) is a rare non epithelial tumour. It usually arises from the smooth muscles of the extremities. It is, however, occasionally reported to arise from other regions of the body.

Selenium levels in neoplastic breast lesions.

Aims And Objectives: The aim of this prospective case controlled study was to evaluate the tissue levels of selenium in patients with cases of fibroadenoma, cancer of the breast and in the controls in order to relate them to the occurrence of breast diseases.

Subjects And Methods: Consecutive consenting patients who had histologically confirmed breast cancer and fibroadenoma attending the General surgical outpatients departments of Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, were recruited for the study. One gram of core disease breast tissues was taken for Selenium level estimation.

Pseudoangiosarcomatous squamous cell carcinoma in an old surgical scar of an African woman.

Background: Squamous cell carcinoma, a malignant proliferation of keratinocytes, can be found in many regions of the body covered by stratified squamous epithelium and in areas covered by other epithelia but which had undergone squamous metaplasia. Squamous cell carcinoma has many variants.

Methodology: We, retrospectively, reviewed the case file and histological features of a 75 year old trader with a rare variant of squamous cell carcinoma arising from an old surgical scar.

The role of the anatomy of the sigmoid colon in developing sigmoid volvulus: a cross-sectional study.

Purpose: The aim of this study was to determine the length of the sigmoid colon and sigmoid mesocolon in living subjects and fresh cadavers.

Methods: The subjects for the study were consecutive 50 living subjects undergoing abdominal surgeries via midline incision and 50 fresh cadavers undergoing a medicolegal postmortem at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

Results: The study showed that the mean length of the sigmoid colon in living subjects was 48.

Histopathological study of salivary gland tumours in Ile-Ife, Nigeria.

Aims And Objectives: The objective of this study is to document the prevalence and clinicopathologic features/pattern of salivary gland tumours in Ile-Ife, southwestern Nigeria.

Patients And Methods: Fifty eight (58) cases of salivary gland tumours histologically diagnosed between January 1989 and December 2007 were identified from the biopsy records of the Departments of Morbid Anatomy and Forensic Medicine and Oral/Maxillofacial Pathology of the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria. The records of the patients were extracted and data on incidence, age, gender and site of the various tumours were analysed using descriptive statistics.

Audit of management of gallbladder cancer in a Nigerian tertiary health facility.

Background: Gallbladder cancer is a rare malignancy with a variable incidence worldwide. It ranks number eight among all gastrointestinal cancer seen in Nigeria. It is associated with high mortality and morbidity because it is usually diagnosed very late.

Testicular and para-testicular tumors in south western Nigeria.

Background: Tumors of the testis and paratesticular tissues are rare, especially in men of African descent. In recent reviews however, the incidence is rising among the Caucasians and black Americans. We set out to determine the incidence in South-Western Nigeria and to examine the histopathologic variants.

Wait time and service satisfaction at Antenatal Clinic, Obafemi Awolowo University Ile-Ife.

Objective: Antenatal care is an essential aspect of health care delivery for improving pregnancy outcome such that about two-thirds of maternal deaths can be prevented. The study was carried out with the aim to assess patient satisfaction on some aspects of antenatal care services (timeliness, courtesy, communication and competence of personnel in the clinic) and estimated time spent in clinic.

Methodology: The study was a cross sectional survey of pregnant mothers attending antenatal clinic of the Obafemi Awolowo University Teaching Hospital Complex within the period of the study.

Leiomyosarcoma of the uterus: a clinicopathological report of two cases and review of literature.

Leiomyosarcomas of the uterus are highly malignant tumours that are rare and represent slightly over 1% of all uterine malignancies. The clinical presentation is fairly constant and includes abnormal vaginal bleeding, pains or both. Only two cases (0.