Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats.

Background: The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride (CoCl ). This study was designed to investigate the role of glycine in the mitigation of hepato-renal toxicities associated with CoCl exposure.

Methods: Forty-two (42) male rats were grouped as Control; (CoCl ; 300 ppm); CoCl  + Glycine (50 mg/kg); CoCl  + Glycine (100 mg/kg); Glycine (50 mg/kg); and Glycine (100 mg/kg).

Naringin abrogates angiotensin-converting enzyme (ACE) activity and podocin signalling pathway in cobalt chloride-induced nephrotoxicity and hypertension.

The persistent and alarming rates of increase in cardiovascular and renal diseases caused by chemicals such as cobalt chloride (CoCl) in mammalian tissues have led to the use of various drugs for the treatment of these diseases. This study aims at evaluating the nephron-protective action of Naringin (NAR), a metal-chelating antioxidant against CoCl-induced hypertension and nephrotoxicity.Forty-two male Wistar rats were randomly distributed to seven rats of six groups and classified into Group A (Control), Group B (300 part per million; ppm CoCl), Group C (300 ppm CoCl + 80 mg/kg NAR), Group D (300 ppm CoCl + 160 mg/kg NAR), Group E (80 mg/kg NAR), and Group F (160 mg/kg NAR).

Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways.

Environmental and occupational exposure to chromium compounds has become potential aetiologic agent for kidney disease with excessive generation of free radicals, apoptosis, and inflammatory. These pathophysiologic mechanisms of potassium dichromate (K Cr O ) have been well correlated with nephrotoxicity and cardiotoxicity. The cardioprotective and nephroprotective effects of Luteolin, a known potent antioxidant were evaluated in this study with 40 healthy rats in four experimental groups: Group A (normal saline), Groups B (30 mg/kg K Cr O ), Group C (Luteolin 100 mg/kg and K Cr O 30 mg/kg), and Group D (Luteolin 200 mg/kg and K Cr O 30 mg/kg), respectively.