Comparative Efficacy and Safety of Thrombectomy Versus Thrombolysis for Large Vessel Occlusion in Acute Ischemic Stroke: A Systemic Review.

Acute ischemic stroke (AIS) is a common cause behind a significant number of people who develop disabilities or die worldwide. Most of the strokes that occur globally are attributed to AIS as a result of large vessel occlusions that typically occur in arteries like the internal carotid and middle cerebral arteries. Primary treatments for AIS are mechanical thrombectomy (MT) and intravenous thrombolysis (IVT), and the clinical scenario can dictate what method would provide the most optimal outcome for the patient.

High dose opioid agonist therapy for patients with opioid use disorder: a case series exploring this patient-centered approach.

Objectives: Management of opioid withdrawal in the inpatient setting can vary widely depending on the patient, the physician, and the institution. Although buprenorphine and methadone are first-line therapy for withdrawal management, some patients experience barriers to those medications. In this case series, we explore high dose opioid agonist therapy (HDOAT) as a novel and effective option to bridge to recovery in this particular setting.

Approaches to the Prevention and Treatment of Postpartum Hemorrhage: A Systematic Review of Past Advances, Recent Developments, and Best Practices.

Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality worldwide, with uterine atony being the most significant contributing factor. Other risk factors for PPH include increased maternal age, coagulation abnormalities, retained placenta, and prolonged third-stage labor. Despite the potential for prevention through early detection and management, PPH can still occur even in the absence of known risk factors.