Publications by authors named "Omnya Elhussieny"
Corrigendum to "Combined sulforaphane and β-sitosterol mitigate against olanzapine-induced metabolic disorders in rats: Insights on FOXO, PI3K/AKT, JAK/STAT3, and MAPK signaling pathways" [Int. Immunopharmacol. 140 (2024) 112904].
Int Immunopharmacol
December 2024
Article Synopsis
- Olanzapine (OLA) is an effective antipsychotic for schizophrenia and bipolar disorder, but it has serious side effects like liver damage and weight gain.
- This study aimed to investigate the metabolic disruption caused by OLA and explore the protective roles of sulforaphane (SFN) and β-sitosterol (βSS) against these effects.
- Results showed that SFN and/or βSS alleviated the adverse biochemical and liver function abnormalities caused by OLA by modulating specific cellular signaling pathways involved in metabolism and inflammation.
Depression is a mood disorder that may increase risk for the development of insulin resistance (IR) and type 2 diabetes (T2D), and vice versa. However, the mechanistic pathway linking depression and T2D is not fully elucidated. The aim of this narrative review, therefore, was to discuss the possible link between depression and T2D.
View Article and Find Full Text PDFEpilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interplay between the reduction of inhibitory gamma-aminobutyric acid (GABA) and the enhancement of excitatory glutamate. Pro-BDNF/p75 expression is augmented in both glial cells and neurons following epileptic seizures and status epileptics (SE).
View Article and Find Full Text PDFBackground: Coronavirus disease 2019 (COVID-19) is a pandemic disease caused by severe acute respiratory syndrome CoV type 2 (SARS-CoV-2). COVID-19 is higher in men than women and sex hormones have immune-modulator effects during different viral infections, including SARS-CoV-2 infection. One of the essential sex hormones is progesterone (P4).
View Article and Find Full Text PDFHypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer's disease (AD). In addition, progressive neurodegeneration in AD may affect the metabolism of thyroid hormones (THs) in the brain causing local brain HPT. Hence, the present review aimed to clarify the potential association between HPT and AD.
View Article and Find Full Text PDFMultiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the central nervous system (CNS) due to injury of the myelin sheath by immune cells. The clotting factor fibrinogen is involved in the pathogenesis of MS by triggering microglia and the progress of neuroinflammation. Fibrinogen level is correlated with MS severity; consequently, inhibition of the fibrinogen cascade may reduce MS neuropathology.
View Article and Find Full Text PDFVinpocetine (VPN) is an ethyl apovincaminate that has anti-inflammatory and antioxidant effects by inhibiting the expression of nuclear factor kappa B (NF-κB) and phosphodiesterase enzyme 1 (PDE-1). VPN is used in the management of stroke, dementia, and other neurodegenerative brain diseases. VPN may be effective in treating Parkinson's disease (PD).
View Article and Find Full Text PDFBackground: Bronchial-associated lymphoid tissue (BALT) is responsible for the local immune response of the lung against airborne infections. The structure of this tissue varies according to species and age.
Aim: The aim of this study was to describe the possible age-related structural variation of the BALT of the one humped camel.