Publications by authors named "Omnia Shadad"
α-synucleinopathies are progressive neurodegenerative disorders characterized by intracellular aggregation of α-synuclein, yet their molecular pathogenesis remains unknow. Here, we explore cell-specific changes in gene expression across different α-synucleinopathies. We perform single-nucleus RNA sequencing on nearly 300,000 nuclei from the prefrontal cortex of individuals with idiopathic Parkinson's disease (iPD, n = 20), Parkinson's disease caused by LRRK2 mutations (LRRK2-PD, n = 7), multiple system atrophy (MSA, n = 6) and healthy controls (n = 13).
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- - Idiopathic Parkinson's disease (iPD) has varying causes, but researchers have identified two specific subtypes based on the severity of neuronal respiratory complex I (CI) deficiency.
- - The CI deficient (CI-PD) subtype, which makes up about 25% of iPD cases, shows widespread CI deficiency and is linked to non-tremor dominant symptoms, along with distinct gene expression and more mitochondrial DNA damage.
- - In contrast, the non-CI deficient (nCI-PD) subtype does not show significant mitochondrial issues outside a specific brain region and is more likely to present with tremor dominant symptoms, offering insights for better understanding and treatment of iPD.
Teeth are richly supported by blood vessels and peripheral nerves. The aim of this study was to describe in detail the developmental time-course and localization of blood vessels during early tooth formation and to compare that to innervation, as well as to address the putative role of vascular endothelial growth factor (VEGF), which is an essential regulator of vasculature development, in this process. The localization of blood vessels and neurites was compared using double immunofluorescence staining on sections at consecutive stages of the embryonic (E) and postnatal (PN) mandibular first molar tooth germ (E11-PN7).
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