Hyrtios sp.-associated Cladosporium sp. UR3 as a potential source of antiproliferative metabolites.

Background: Sponge-associated microorganisms are promising resources for the production of bioactive compounds with cytotoxic potential. The main goal of our study is to isolate the fungal endophytes from the Red Sea sponge Hyrtios sp. followed by investigating their cytotoxicity against number of cell lines.

Tamarix aphylla derived metabolites ameliorate indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway, alleviating oxidative stress and inflammation: In vivo study supported by pharmacological network analysis.

Nature has proven to be a treasure resource of bioactive metabolites. In this regard, Tamarix aphylla (F. Tamaricaceae) leaves crude extract was investigated for its gastroprotective effect against indomethacin-induced damage to the gastric mucosa.

Pro-Apoptotic Activity of -Obtusane against Cervical Cancer: Nano Formulation, In Silico Molecular Docking, and Pharmacological Network Analysis.

Cancer is a major disease that threatens human health all over the world. Intervention and prevention in premalignant processes are successful ways to prevent cancer from striking. On the other hand, the marine ecosystem is a treasure storehouse of promising bioactive metabolites.

Anti-infective potential of the endophytic fungus sp. associated with root supported by metabolomics analysis and docking studies.

Endophytic fungi are known to be a rich source for anti-infective drugs. In this study, associated endophytic fungi were explored for the first time. Seven isolates were identified morphologically followed by screening of these fungi by plug diffusion assay which revealed their potential activity against (ATCC 9144), (ATCC 14579), (ATCC 14756), (ATCC 48112), and (ATCC 22546).

Seed Extract Exhibits In Vitro and In Vivo Anti-Alzheimer's Potential Supported by Metabolomic and Computational Investigation.

Linn. (okra, F. Malvaceae) is a fruit widely consumed all over the world.

The anti-infective potential of the endophytic fungi associated with supported by metabolomics analysis and docking studies.

Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, was investigated for fungal diversity using different media to give 11 isolates which were identified morphologically. Out of the isolated fungal strains, sp.

Chemical and biological studies on the soft coral sp.

Soft corals belonging to the family Nephtheidae have been appreciated as marine sources of diverse metabolites with promising anticancer potential. In view of that, the current work investigates the anti-proliferative potential of the crude extract, different fractions, and green synthesized silver nanoparticles (AgNPs) of the Red Sea soft coral, sp. against a panel of tumor cell lines.

Cytotoxic potential of sp.-derived actinomycetes supported by metabolomics analysis.

Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, sp.; a Red Sea soft coral was investigated for the first time using the OSMAC approach.

Natural metabolites from the soft coral sp. as potential SARS-CoV-2 main protease inhibitors.

The ongoing spread of SARS-CoV-2 has created a growing need to develop effective antiviral treatments; therefore, this work was undertaken to delve into the natural metabolites of the Red Sea soft coral sp. (family Nephtheidae) as a source of potential anti-COVID-19 agents. Overall, a total of 14 structurally diverse minor constituents were isolated and identified from the petroleum ether fraction of sp.

Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Sp. Supported by Metabolomics Analysis and Docking Studies.

Background: Soft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential as source of anti-inflammatory metabolites has stimulated a growing research interest.

Purpose: To investigate the anti-inflammatory potential of the soft coral, sp., in its bulk and silver nanostructure.

Metabolomics analysis and biological investigation of three Malvaceae plants.

Introduction: Metabolomics is a fast growing technology that has effectively contributed to many plant-related sciences and drug discovery.

Objective: To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H.

Recent Updates on Corals from Nephtheidae.

Marine natural products display a wide range of biological activities, which play a vital role in the innovation of lead compounds for the drug development. Soft corals have been ranked at the top in regard to the discovery of bioactive metabolites with potential pharmaceutical applications. Many of the isolated cembranoids revealed diverse biological activities, such as anticancer, antidiabetic and anti-osteoporosis.

Hepatoprotective potential of Malvaviscus arboreus against carbon tetrachloride-induced liver injury in rats.

Malvaviscus arboreus Cav. is a medicinal plant belonging to family Malvaceae with both ethnomedical and culinary value; however, its phytochemical and biological profiles have been scarcely studied. Accordingly, this work was designed to explore the chemical composition and the hepatoprotective potential of M.