Publications by authors named "Omkar R Valanju"
Article Synopsis
- - The MYCN oncoprotein works with another protein called MAX to attach to active gene promoters, and it also connects with the nuclear exosome, indicating its role in RNA processing.
- - Research shows that MYCN forms large complexes with the exosome and various RNA-binding proteins, binding to RNA through a specific region known as MYCBoxI, which helps process many intronic RNA transcripts in cells.
- - Disrupting the exosome alters MYCN's position from gene promoters to intronic RNAs, leading to a shift in its role from activating genes to being replaced by a repressor (MNT/MXD6), which can limit its ability to influence cell growth while being crucial for neuroblastoma cell
Tautomerism is an important phenomenon exhibited by many drugs. As we discuss in this review, identifying the different tautomers of drugs and exploring their importance in the mechanisms of drug action are integral components of current drug discovery. Nuclear magnetic resonance (NMR), infrared (IR), ultraviolet (UV), Raman, and terahertz spectroscopic techniques, as well as X-ray diffraction, are useful for exploring drug tautomerism.
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