Dynamic Thermodynamic Resolution of Racemic 1,1'-Binaphthyl-2,2'-diol (BINOL).

A dynamic thermodynamic resolution method for converting (/)-BINOL (1,1'-binaphthyl-2,2'-diol) into ()-BINOL in 100% theoretical yield is reported. This technique involves mixing (/)-BINOL with -benzyl cinchonidinium bromide (1 equiv) and a [Cu(tmeda)(μ-OH)]Br (2.5 mol %) redox catalyst in acetonitrile.

Multicopper Clusters Enable Oxidative Phenol Macrocyclization (OxPM) of Peptides.

The biosynthesis of glycopeptide antibiotics such as vancomycin and other biologically active biaryl-bridged and diaryl ether-linked macrocyclic peptides includes key enzymatic oxidative phenol macrocyclization(s) of linear precursors. However, a simple and step-economical biomimetic version of this transformation remains underdeveloped. Here, we report highly efficient conditions for preparing biaryl-bridged and diaryl ether-linked macrocyclic peptides based on multicopper(II) clusters.