Translating Akkadian to English with neural machine translation.

Cuneiform is one of the earliest writing systems in recorded human history (ca. 3,400 BCE-75 CE). Hundreds of thousands of such texts were found over the last two centuries, most of which are written in Sumerian and Akkadian.

Shared computational principles for language processing in humans and deep language models.

Departing from traditional linguistic models, advances in deep learning have resulted in a new type of predictive (autoregressive) deep language models (DLMs). Using a self-supervised next-word prediction task, these models generate appropriate linguistic responses in a given context. In the current study, nine participants listened to a 30-min podcast while their brain responses were recorded using electrocorticography (ECoG).

Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies.

Cancer cells depend on actin cytoskeleton rearrangement to carry out hallmark malignant functions including activation, proliferation, migration and invasiveness. Wiskott-Aldrich Syndrome protein (WASp) is an actin nucleation-promoting factor and is a key regulator of actin polymerization in hematopoietic cells. The involvement of WASp in malignancies is incompletely understood.

Emergent linguistic structure in artificial neural networks trained by self-supervision.

This paper explores the knowledge of linguistic structure learned by large artificial neural networks, trained via self-supervision, whereby the model simply tries to predict a masked word in a given context. Human language communication is via sequences of words, but language understanding requires constructing rich hierarchical structures that are never observed explicitly. The mechanisms for this have been a prime mystery of human language acquisition, while engineering work has mainly proceeded by supervised learning on treebanks of sentences hand labeled for this latent structure.

A conformational change within the WAVE2 complex regulates its degradation following cellular activation.

WASp family Verprolin-homologous protein-2 (WAVE2), a member of the Wiskott-Aldrich syndrome protein (WASp) family of actin nucleation promoting factors, is a central regulator of actin cytoskeleton polymerization and dynamics. Multiple signaling pathways operate via WAVE2 to promote the actin-nucleating activity of the actin-related protein 2/3 (Arp2/3) complex. WAVE2 exists as a part of a pentameric protein complex known as the WAVE regulatory complex (WRC), which is unstable in the absence of its individual proteins.