Lanthanide and functionalization-free dual-state emitting zinc-based MOFs followed by dual-state detection: ratiometric and color-tonality visual detection of tetracycline in solution and on paper in food and environmental samples.

An efficient dual-state blue-emitting zinc-based metal-organic frameworks (MOFs), designated as UoZ-8 has been developed. Coordination-induced emission causes the UoZ-8 to give the blue emission in both solid and dispersed form in liquid. Upon the addition of tetracycline (TC), a noticeable shift from blue emission to greenish-yellow emission occurred, with a marked increase in intensity, which was attributed to the inner filter effect accompanied by aggregation-induced emission (IFE-AIE).

Multifunctional MOF: Cold/hot adapted sustainable oxidase-like MOF nanozyme with ratiometric and color tonality for nitrite ions detection.

Integrating multiple functionalities into a single entity is highly important, especially when a broad spectrum of application is required. In the present work, we synthesized a novel manganese-based MOF (denoted as UoZ-6) that functions as a cold/hot-adapted and recyclable oxidase nanozyme (Km 0.085 mM) further developed for ratiometric-based colorimetric and color tonality visual-mode detection of nitrite in water and food.

Promoting gender equity in a home visits programme: a qualitative study in Northern Nigeria.

Background: Gender inequities remain critical determinants influencing maternal health. Harmful gender norms and gender-based violence adversely affect maternal health. Gendered division of labour, lack of access to and control of resources, and limited women's decision-making autonomy impede women's access to maternal healthcare services.

Role of wearable electrochemical biosensors in monitoring renal function biomarkers in sweat: a review.

Real-time detection of renal biomarkers is crucial for immediate and continuous monitoring of kidney function, facilitating early diagnosis and intervention in kidney-related disorders. This proactive approach enables timely adjustments in treatment plans, particularly in critical situations, and enhances overall patient care. Wearable devices emerge as a promising solution, enabling non-invasive and real-time data collection.

Enhanced antibacterial activity of a novel silver-based metal organic framework towards multidrug-resistant .

The growth and spread of multidrug-resistant bacterial species, such as , pose a serious threat to human health and require the development of innovative antibacterial agents. The search for an acceptable, safe, and efficient antibacterial is a matter of significant concern. In the present work, silver-based metal-organic frameworks (Ag-MOFs) showed efficient antibacterial activity against multidrug-resistant (KBP 11) with a minimum inhibitory concentration and minimum bactericidal concentration of 10 μg mL.

Three in one: coordination-induced emission for inherent fluorescent Al-MOF synthesis combined with inner filter effect@aggregation-induced emission mechanisms for designing color tonality and ratiometric sensing platforms.

Three phenomena, namely coordination-induced emission (CIE), aggregation-induced emission (AIE), and inner filter effect (IFE), were incorporated into the design of a ratiometric and color tonality-based biosensor. Blue fluorescent Al-based metal-organic frameworks (FMIL-96) were prepared from non-emissive ligand and aluminum ions via CIE. Interestingly, the addition of tetracycline (TC) led to ratiometric detection and color tonality, as the blue emission at 380 nm was quenched (when excited at 350 nm) due to IFE, while the green-yellowish emission at 525 nm was enhanced due to AIE.

Portable on-off visual-mode detection using intrinsic fluorescent zinc-based metal-organic framework for detection of diclofenac in pharmaceutical tablets.

On-site, robust, and quantitative detection of diclofenac (DCF) is highly significant in bioanalysis and quality control. Fluorescence-based metal-organic frameworks (MOFs) play a pivotal role in biochemical sensing, offering a versatile platform for detecting various biomolecules. However, conventional fluorescent MOF sensors often rely on lanthanide metals, which can pose challenges in terms of cost, accessibility, and environmental impact.

The Equity Impact of Universal Home Visits to Pregnant Women and Their Spouses in Bauchi State, Nigeria: Secondary Analysis From a Cluster Randomised Controlled Trial.

Background: Socio-economically disadvantaged women have poor maternal health outcomes. Maternal health interventions often fail to reach those who need them most and may exacerbate inequalities. In Bauchi State, Nigeria, a recent cluster randomised controlled trial (CRCT) showed an impressive impact on maternal health outcomes of universal home visits to pregnant women and their spouses.

Temperature-resilient and sustainable Mn-MOF oxidase-like nanozyme (UoZ-4) for total antioxidant capacity sensing in some citrus fruits: Breaking the temperature barrier.

Current nanozyme applications rely heavily on peroxidase-like nanozymes and are limited to a specific temperature range, despite notable advancements in nanozyme development. In this work, we designed novel Mn-based metal organic frameworks (UoZ-4), with excellent oxidase mimic activity towards common substrates. UoZ-4 showed excellent oxidase-like activity (with Km 0.

A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu and Fe in drinking water using a fluorescent MOF@tetracycline nanocomposite.

The regular and on-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems. Thus, developing a portable analytical device for the rapid, cost-effective, and visual on-site detection of multiple environmental pollutants is notably significant. In the present work, a novel ratiometric microfluidic paper-based analytical device (μPAD) was designed and developed for the simultaneous detection of Fe and Cu ions in water samples taking advantages from built-in masking zone.

Added value of video edutainment on android handsets in home visits to improve maternal and child health in Bauchi State, Nigeria: Secondary analysis from a cluster randomised controlled trial.

Objective: A trial of evidence-based health promotion home visits to pregnant women and their spouses in northern Nigeria found significant improvements in maternal and child health outcomes. This study tested the added value for these outcomes of including video edutainment in the visits.

Methods: In total, 19,718 households in three randomly allocated intervention wards (administrative areas) received home visits including short videos on android handsets to spark discussion about local risk factors for maternal and child health; 16,751 households in three control wards received visits with only verbal discussion about risk factors.

Dual-state dual emission from precise chemically engineered bi-ligand MOF free from encapsulation and functionalization with self-calibration model for visual detection.

Synthesis of dual-state dual emitting metal-organic frameworks (DSDE-MOFs) is uncommon and challenging. Additionally, DSDE-MOFs can fulfil the expanding need for on-site detection due to their stability and self-reference for a variety of non-analyte variables. In the present work, a novel intrinsic DSDE of chemically engineered bi-ligand Eu-based MOF (UoZ-1) was designed.

Gold single atom-based aptananozyme as an ultrasensitive and selective colorimetric probe for detection of thrombin and C-reactive protein.

An ultra-efficient biocatalytic peroxidase-like Au-based single-atom nanozyme (Au-SAzymes) has been synthesized from isolated Au atoms on black nitrogen doped carbon (Au-N-C) using a simple complexation-adsorption-pyrolysis method. The atomic structure of AuN centers in black carbon was revealed by combined high-resolution transmission electron microscopy/high-angle annular dark-field scanning transmission electron microscopy. The Au-SAzymes showed a remarkable peroxidase activity with 1.

Community Groups Co-Design Evidence-Based Docudramas to Communicate About Child Spacing in Bauchi State, Nigeria: A Qualitative Descriptive Study.

In Bauchi State, northern Nigeria, communities recognise short birth interval ( in the Hausa language) as harmful, but family planning is a sensitive topic. This paper describes the development of a culturally safe way to communicate about in a conservative Muslim setting. The objective was to co-design culturally safe communication material, based on local knowledge about short birth interval, to share with women and men in households.

Dual-spot ratiometric microfluidic paper-based analytical device for accuracy and precision improvement.

Instrumental and environmental fluctuations are common sources of error in smartphone-based optical detection, significantly affecting the accuracy of analytical measurements. In this regard, spotting the sample and reference simultaneously and in close proximity compensates for the fluctuations. This "dual-spot" design is similar to the double-beam technique used in spectrophotometry, which reduces fluctuations in the results.

Determinants of Adolescent Sexual and Reproductive Health in Sub-Saharan Africa: Protocol for an Umbrella Review.

Background: Adolescents are a large proportion of the population in sub-Saharan Africa and face multiple risks to their health and well-being. Prior systematic reviews have focused on specific adolescent sexual and reproductive health outcomes such as teen pregnancies, HIV/AIDS, and sexually transmitted diseases. A comprehensive synthesis of the influential factors that shape different aspects of adolescent sexual and reproductive health can inform health policy and program development for this important segment of the population.

Intrinsic Dual-State Emission Zinc-Based MOF Rodlike Nanostructures with Applications in Smartphone Readout Visual-Based Detection for Tetracycline: MOF-Based Color Tonality.

Dual-state emitters (DSEs) are entities that exhibit fluorescence in both the solution and solid state, which open up a wide range of possibilities for their utilization in various fields. The development of detection platforms using intrinsic luminescent metal-organic frameworks (LMOFs) is highly desirable for a variety of applications. DSE MOFs as a subclass of intrinsic LMOFs are highly attractive due to no need for encapsulation/functionalization by fluorophores and/or using luminescent linkers.

Pulse Pressure: A Predictor of Intervention in Blunt Abdominal Trauma.

Background: Patients with life-threatening hemorrhages due to blunt torso trauma are at a particularly high risk of being underdiagnosed. The pulse pressure (PP) starts narrowing down before the traditional parameters start changing, making it a useful tool for assessing and planning early intervention.

Objective: To assess the utility of low PP in predicting massive transfusion (MT) or operative intervention in patients with isolated blunt abdominal trauma.

Heavy metal pollution in the aquatic environment: efficient and low-cost removal approaches to eliminate their toxicity: a review.

Heavy metal contamination of water sources has emerged as a major global environmental concern, threatening both aquatic ecosystems and human health. Heavy metal pollution in the aquatic environment is on the rise due to industrialization, climate change, and urbanization. Sources of pollution include mining waste, landfill leachates, municipal and industrial wastewater, urban runoff, and natural phenomena such as volcanic eruptions, weathering, and rock abrasion.

Accuracy improvement novel ratiometry design in distance-based microfluidic paper based analytical device: instrument-free point of care testing.

Developing accurate, precise, instrument-free, and point-of-need microfluidic paper-based devices is highly significant in clinical diagnosis and biomedical analysis. In the present work, a ratiometric distance-based microfluidic paper-based analytical device (R-DB-μPAD), along with a three-dimensional (3D) multifunctional connector (spacer), was designed to improve the accuracy and detection resolution analyses. Specifically, the novel R-DB-μPAD was used for the accurate and precise detection of ascorbic acid (AA) as a model analyte.

Deep insights to explain the mechanism of carbon dot formation at various reaction times using the hydrothermal technique: FT-IR, C-NMR, H-NMR, and UV-visible spectroscopic approaches.

A well-explained mechanism for synthesizing carbon dots (CDs) is not yet explored and is still a subject of great debate and challenge. This study used a one-step hydrothermal method to prepare highly efficient, gram-scale, excellent water solubility, and blue fluorescent nitrogen-doped carbon dots (NCDs) with the particle size average distribution of around 5 nm from 4-aminoantipyrine. The effects of varying synthesis reaction times on the structure and mechanism formation of NCDs were investigated using spectroscopic methods, namely FT-IR, C-NMR, H-NMR, and UV-visible spectroscopies.

Enhanced Peroxidase-Mimic Catalytic Activity via Cerium Doping of Strontium-Based Metal-Organic Frameworks with Design of a Smartphone-Based Sensor for On-Site Salivary Total Antioxidant Capacity Detection in Lung Cancer Patients.

The development of artificial nanozymes with superior catalytic performance and excellent stability has been a long-standing objective for chemists. The total antioxidant capacity (TAC) is one of the most important bioanalytical measures of oxidative stress in the body. The present work aims to develop a smartphone-assisted visual detection sensor using cerium-doped strontium-based metal-organic frameworks (Ce-SrMOFs) as peroxidase-like nanozymes for the rapid, low-cost, on-site detection of TAC.

Green nanocomposite: fabrication, characterization, and photocatalytic application of vitamin C adduct-conjugated ZnO nanoparticles.

Recently, the conjugation of metal oxide nanoparticles with organic moieties has attracted the attention of many researchers for various applications. In this research, the green and biodegradable vitamin C was employed in a facile and inexpensive procedure to synthesize the vitamin C adduct (3), which was then blended with green ZnONPs to fabricate a new composite category (ZnONPs@vitamin C adduct). The morphology and structural composition of the prepared ZnONPs and their composites were confirmed by several techniques: Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), UV-vis differential reflectance spectroscopy (DRS), energy dispersive X-ray (EDX) analysis, elemental mapping, X-ray diffraction (XRD) analysis, photoluminescence (PL) spectroscopy, and zeta potential measurements.