The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle.

Objectives: The pain assocaited with ureteral obstruction is caused by a rise in intraluminal pressure above the obstruction which produces an increase in tension of the ureteral smooth muscle. A reduction in pressure will result in decreased tension and relief of pain. In this study we used papaverine and a prostaglandin synthesis inhibitor, diclofenac sodium to decrease ureteral tension and compaired their effects on isolated human ureteric smooth muscle.