Publications by authors named "Omer F Mutaf"
Article Synopsis
- Researchers are working on delivering antibodies directly into cells, but success has been limited due to challenges with current delivery systems.
- A new method involves creating polyion complex (PIC) micelles that enhance stability and release of antibodies inside cells.
- By using citraconic anhydride for charge modification, the micelles can remain stable outside cells but break down in acidic environments, improving the delivery and effectiveness of the antibodies against target antigens.
Article Synopsis
- PIC formation offers an easy way to create molecular assemblies in water, but more understanding is needed for controlling complex structures made from polypeptides.
- Research focused on the interactions between oppositely charged homochiral polypeptides, like poly-L-lysine and PEG-PLG, showing that β-sheet structures emerge when polymer concentrations are above 0.3 mg mL(-1).
- Factors like PEG weight ratio, polypeptide stereochemistry, and solution ionic strength play significant roles in determining the secondary structure, suggesting these can help fine-tune the assembly of water-soluble nanoassemblies for potential applications in biological systems.
We report the use of reverse PS-b-P2VP diblock copolymer micelles as true nanoscale-sized reactor vessels to synthesize ZnO nanoparticles. The reverse micelles were formed in toluene and then sequentially loaded with zinc acetate dihydrate and tetramethylammonium hydroxide reactants. Moreover, high spatial resolution Z-contrast imaging and EDX spectroscopy techniques were used to confirm the segregation of the Zn cation to the core of the loaded micelles.
View Article and Find Full Text PDFUnder energy-dissipative cantilevered tip-sample interaction, phase imaging using tapping-mode atomic force microscopy enables compositional mapping of composites containing a harder inorganic phase at the nanometer scale, embedded in a polymer matrix. The contrast in the phase images is shown to be dependent on the variation in the elastic properties of the diblock copolymer reverse micelles loaded with zinc acetate. Tapping conditions are also shown to determine whether the contrast is positive or negative for the harder core of the loaded micelles, based on the competition between attractive and repulsive tip-sample interaction forces.
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