A functional SNP in miR-146a and genetic susceptibility to drug-resistant epilepsy.

Objectives: The study aimed to assess the relationship between the functional single nucleotide polymorphism (SNP) (rs57095329) of miR-146a, the progression of drug-resistant epilepsy (DRE), and the severity of the disease (seizure frequency) in a group of Egyptian children epilepsy patients.

Subjects And Methods: 110 Egyptian children were recruited and divided into two groups, the epilepsy patients ( = 60) and the healthy control children ( = 50). The patient's group was equally subdivided into two subgroups: drug-resistant and drug-responsive epilepsy patients.