Bed occupancy and nosocomial infections in the intensive care unit: A retrospective observational study in a tertiary hospital.

Background: Healthcare-associated infections (HAI) are a major problem globally, contributing to prolonged hospital admissions and poor outcomes.

Objectives: To examine HAI incidence and risk factors in an intensive care unit (ICU) during high v. low occupancy periods.

Assessing intrinsic capacity for person-centred HIV care: a cross-sectional study in ageing populations in Malaysia and Hong Kong.

Introduction: WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age-associated vulnerabilities. Assessments of IC may be useful to address the evolving, non-HV care needs of ageing people with HIV (PWH). However, to date, its utility within the context of HIV has not been assessed.

Length of stay and its associated factors in the neonatal intensive care unit of Gadarif Hospital, Eastern Sudan: a retrospective study.

Background: Attention is increasingly paid to length of stay (LOS) in neonatal intensive care units (NICUs) across countries. Few published data on neonatal LOS exist in Africa, where there is a high burden of neonatal morbidity and mortality. Thus, this study investigated the factors associated with neonatal LOS in the NICU of Gadarif Hospital, Eastern Sudan.

Biosynthesis of Silver, Copper, and Their Bi-metallic Combination of Nanocomposites by : Their Antimicrobial, Anticancer Activity, and Cytotoxicity Effect.

Unlabelled: The present study outlines an easy, cheap, and environmentally friendly way to make -mediated bimetallic silver-copper nanocomposites (Ag/Cu) that can fight cancer and germs. The gram-positive synthesized Ag, Cu, and their bi-metallic nanocomposites extracellularly. We aimed to prepare the bimetallic nanocomposite in two different ways, and we compared them in terms of characterization and biological applications.

Genetic polymorphism association of (, and ) with acute lymphocytic leukemia in Saudi Arabia.

Human leukocyte antigen-G () is linked to the development of human malignancies via immune escape mechanisms. The chief variations for were found in three prime untranslated regions (3'UTR). The current study aims to evaluate the distribution of (), , and polymorphisms with risk of acute lymphocytic leukemia (ALL) in Saudi Arabia.

Systematic review and meta-analysis of protocols and yield of direct from sputum sequencing of .

Direct sputum whole genome sequencing (dsWGS) can revolutionize () diagnosis by enabling rapid detection of drug resistance and strain diversity without the biohazard of culture. We searched PubMed, Web of Science and Google scholar, and identified 8 studies that met inclusion criteria for testing protocols for dsWGS. Utilising meta-regression we identify several key factors positively associated with dsWGS success, including higher bacillary load, mechanical disruption, and enzymatic/chemical lysis.

Takayasu arteritis masquerading as brucellosis: a case report.

This study reports a unique case of a 19-year-old male with Takayasu arteritis initially misdiagnosed as brucellosis due to persistently positive brucella serology. Despite multiple anti-brucellosis treatments, symptoms persisted until the correct diagnosis of Takayasu arteritis was made, Subsequent immunosuppressive therapy for Takayasu arteritis led to symptom improvement and normalization of serological markers. This highlights the challenge of distinguishing between these conditions and the potential for immunosuppression to impact brucella serology in such cases.

Investigating the causal links between inflammatory cytokines and scoliosis through bidirectional Mendelian randomization analysis.

Background: Scoliosis, characterized by a lateral curvature of the spine, affects millions globally. The role of inflammatory cytokines in the pathogenesis of scoliosis is increasingly acknowledged, yet their causal relationships remain poorly defined.

Aims: This study aims to explore the genetic-level causal relationships between inflammatory cytokines and scoliosis utilizing bidirectional Mendelian randomization (MR) analysis.

Preparation of polyclonal antibody to CHOP protein and its application in heat stress of chickens.

Heat stress (HS) is a stress response of organisms to temperature changes, which can result in organ damage and increased chicken mortality in high-temperature environments. The CHOP protein, also known as GADD 135, plays a crucial role in endoplasmic reticulum stress. However, there are fewer studies related to whether CHOP proteins are involved in heat stress-induced organ damage.

Skin adnexal carcinoma of the eyelid: A case report.

Skin adnexal carcinomas (SACs) represent a diverse range of cancerous growths originating from the appendages of the skin. SACs are exceedingly rare malignancies that primarily manifest in individuals with fair skin and predominantly affect the head and neck. In the present study, a 70-year-old male presented with swelling and redness around the right eye, accompanied by skin desquamation.

Rehabilitation and violence-related traumatic brain injury: A scoping review.

Objectives: There is a dearth of reviews exploring rehabilitation for violence-related traumatic brain injury (TBI) despite its increasing rates and distinct risk factors and outcomes. The aim of this scoping review is to determine the extent to which rehabilitation is available to and accessed by people who sustain TBI from interpersonal violence.

Method: Electronic databases (i.

Effectiveness of Field Simulation Approach for Problem-Based Learning That Incorporates the One Health Concept.

One Health problem-based learning (PBL) is known as an effective method in teaching zoonotic diseases. However, the classic classroom setting limits real-life exposure for students. Simulation-based learning may improve the learning experience without exposing the students to unnecessary risks.

Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows.

Background: Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of molecular tools for comprehensive drug resistance profiling is imperative for successful detection and characterisation of tuberculosis drug resistance. We aimed to assess the diagnostic accuracy of a new class of molecular diagnostics for drug-resistant tuberculosis.

The prevalence of hydatid cyst in raw meat products: a global systematic review, meta-analysis, and meta-regression.

Hydatid cyst contamination in food presents a persistent and pervasive threat to public health. Hence, several studies have been published on hydatid cysts in raw meat products. The current study aimed to meta-analyze the prevalence of hydatid cysts in meat.

Mortality of patients with sepsis in intensive care units at tertiary hospitals in Jordan: Prospective cohort study.

The aim of this study was to describe the 30-day mortality rate of adult patients with sepsis and septic shock in 6 intensive care units of 2 tertiary hospitals in Jordan. A prospective cohort design was used. Patients with sepsis and septic shock admitted to the medical and surgical intensive care units at 2 tertiary hospitals were followed up during the period between February 2022 and June 2022 (N = 148).

Identifying Abusive Head Trauma in an Infant.

Abusive head trauma (AHT) is a type of neurotrauma that accounts for significant morbidity and mortality. It is characterized by a constellation of neurologic and radiologic signs indicative of abuse in children aged zero to five years. Detection of these cases could be a challenging endeavor and is entirely contingent on the acumen of the healthcare professionals.

Dietary Tributyrin Improves Growth Performance, Meat Quality, Muscle Oxidative Status, and Gut Microbiota in Taihe Silky Fowls under Cyclic Heat Stress.

Heat stress adversely affects poultry production and meat quality, leading to economic losses. This study aimed to investigate the effects of adding tributyrin on growth performance, meat quality, muscle oxidative status, and gut microbiota of Taihe silky fowls under cyclic heat stress (CHS) conditions. In this study, 120-day-old Taihe silky fowls (male) were randomly divided into six dietary treatments.

Upper, middle, and lower CALYX accesses for prone percutaneous nephrolithotomy: a comparative study.

Objective: To compare upper, middle and lower calyceal accesses for prone percutaneous nephrolithotomy regarding stone-free rates, residual stones, haemoglobin drop and fluoroscopic time.

Methods: The prospective comparative clinical study was conducted from September 2018 to March 2021 at Al- Yarmouk Teaching Hospital, Baghdad, Iraq, and comprised patients of either gender aged 18-78 years with renal stones treated with percutaneous nephrolithotomy. They were divided into three groups on the basis of calyx access: upper calyx G1, mid-calyx G2, and lower calyx G3.

Effect of Long COVID on Work Performance and Annual Monetary Loss among Infected Healthcare Workers at a Tertiary Hospital in Malaysia.

Objective: To assess and compare the work performance loss (absenteeism and presenteeism) and the estimated annual monetary loss among healthcare workers with and without Long COVID.

Methods: A retrospective cohort study was conducted between October 2022 and April 2024 using an online questionnaire. The shortened version of the Health and Work Performance Questionnaire was used to estimate the work performance effect among healthcare workers with a history of COVID-19 infection.

Assessing solubility of meloxicam in age-specific gastric and intestinal media relevant to adults and pediatric populations: implications for optimizing dosing in patients for postoperative pain.

Background: Oral dose formulations must be soluble in gastrointestinal fluids for systemic absorption. The solubility of meloxicam was determined in 16 different age-specific simulated gastric and intestinal media that mirrored the microenvironments in pediatrics and adults.

Methods: The solubility of meloxicam in the 16 different age-specific simulated gastric and intestinal biorelevant media was assessed using the standard US pharmacopeial method.

Appendicular diverticulosis complicated by acute appendicitis and organizing abscess: what does the surgeon need to consider intraoperatively?

Acute appendicitis is a common surgical emergency, affecting 7%-10% of people worldwide, whereas appendicular diverticulosis is rare, occurring in 0.004%-2.1% of appendectomy cases and often mimicking appendicitis symptoms.