Publications by authors named "Omar Moustafa Fathy Omar"
Background: The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer's disease (AD). BACE1 is the sole β-secretase for Aβ generation, making it an attractive therapeutic target for AD therapy. While BACE1 inhibitors have been shown to reduce Aβ levels in people with AD, clinical trials targeting BACE1 have failed due to unwanted synaptic deficits.
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- The study aimed to find a connection between machine learning-analyzed CT body composition and 90-day mortality rates after a medical procedure called transjugular intrahepatic portosystemic shunt (TIPS), while also comparing it to the existing MELD score for mortality prediction.
- Researchers conducted a retrospective analysis involving 122 patients who had CT scans before their TIPS procedure and were tracked for at least 90 days post-surgery.
- Results showed that higher MELD scores and lower skeletal muscle and fat measurements were associated with increased 90-day mortality, indicating that certain body composition metrics could help predict patient outcomes alongside the MELD score.
Purpose: To examine the natural history of splenic artery aneurysms (SAAs) at a single institution and assess the effect of patient factors and aneurysm characteristics on aneurysm growth.
Materials And Methods: This single-center retrospective study included patients with SAAs who underwent serial imaging over 30 years (1990-2020). Data regarding patient demographics and aneurysm characteristics were collected.