Publications by authors named "Omar M Hamza"

Parasitic infections are responsible for significant morbidity and mortality throughout the world. Management strategies rely primarily on antiparasitic drugs that have side effects and risk of drug resistance. Therefore, novel strategies are needed for treatment of parasitic infections.

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The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs are toxic and prolonged with poor patient compliance. In addition, emergence of drug-resistant parasites is increasing worldwide.

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Article Synopsis
  • New treatments for leishmaniasis are needed due to the toxicity and poor compliance associated with current medications like antimonials.
  • This study evaluated the effectiveness of oral ibrutinib in treating visceral leishmaniasis (VL), showing it was more effective than the standard treatment.
  • Ibrutinib enhanced the immune response by increasing specific immune cell activity and cytokine production, suggesting it could be a promising new treatment for VL.
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