Publications by authors named "Omar Karam"

The term "Internet of Things" (IoT) refers to a system of networked computing devices that may work and communicate with one another without direct human intervention. It is one of the most exciting areas of computing nowadays, with its applications in multiple sectors like cities, homes, wearable equipment, critical infrastructure, hospitals, and transportation. The security issues surrounding IoT devices increase as they expand.

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Breast cancer is the second most frequent cancer worldwide, following lung cancer and the fifth leading cause of cancer death and a major cause of cancer death among women. In recent years, convolutional neural networks (CNNs) have been successfully applied for the diagnosis of breast cancer using different imaging modalities. Pooling is a main data processing step in CNN that decreases the feature maps' dimensionality without losing major patterns.

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The field of medicinal chemistry is currently witnessing a deuterium rush owing to the remarkable properties of this element as bioisoster of hydrogen atom. Aromatic hydrogen isotope exchange (HIE) is one of the most studied strategies nowadays as it promises to access deuterium-modified drugs directly from their non-labeled parents. While most of the recent studies focus on metal-catalyzed C-H activation strategy, the use of superacidic conditions has been largely overlooked.

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Breast cancer is one of the most common diseases among women worldwide. It is considered one of the leading causes of death among women. Therefore, early detection is necessary to save lives.

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Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF , the chlorination and iodination of classically inert Csp -H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

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A series of substituted pyrrolidines and piperidines were synthesized using superacid HF/SbF5 chemistry. Investigated as inhibitors of several human carbonic anhydrase (hCA, EC 4.2.

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This paper describes the scope and limitations of the hydrofluorination reaction in superacid HF/SbF(5). On the basis of experimental studies of polyfunctional substrates' behaviour, the dramatic effect of substitution on the superelectrophilic character of ammonium-carbenium dications was emphasized. This reaction was applied to the synthesis of novel fluorinated key building blocks.

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A range of unsaturated amines and sulfonamides were converted to beta-fluoro nitrogen analogues after hydrofluorination in superacid HF-SbF(5), based on the formation of highly reactive electrophilic intermediates.

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