Fracture resistance of monolithic gradient zirconia crowns with different finish line designs and cement spaces.

Objective: This study was aimed at assessing the effects of various finish line designs and cement gap thicknesses on the fracture resistance of gradient zirconia crowns.

Methods: Sixty crowns were fabricated on stainless-steel dies with yttria multi-layered (YML) zirconia and categorized into three primary groups according to finish line type (knife-edge, chamfer, and rounded shoulder). Each group was further classified into two subgroups (n = 10) according to cement space thickness (50 or 80 μm).

Safety and Efficacy of Metformin for Idiopathic Intracranial Hypertension. A U.S-Based Real-World Data Retrospective Multicenter Cohort Study.

Introduction: Idiopathic intracranial hypertension (IIH) remains a challenging condition to manage, with limited therapeutic options. This study investigated the potential of metformin as a novel treatment for IIH, exploring its effects on disease outcomes and safety profile.

Methods: We conducted a retrospective cohort study using the TriNetX database, analyzing data from 2009 to August 2024.

A Rare Case of Bicalutamide-Induced Severe Congestive Heart Failure in a Patient With Advanced Prostate Cancer.

Bicalutamide, a nonsteroidal androgen receptor inhibitor, is an established therapeutic agent for advanced prostate cancer but is associated with severe cardiovascular side effects in rare cases. This case report discusses a rare occurrence of severe systolic congestive heart failure (CHF) in a 68-year-old male undergoing treatment for advanced prostate cancer with bicalutamide, without concurrent use of gonadotropin-releasing hormone antagonists. The patient presented with non-specific abdominal and bilateral foot pain.

A virtual reality environment for supporting mental wellbeing of students on remote clinical placement: A multi-methods evaluation.

Background: Nursing and Allied Health Profession (NAHP) students undertake clinical placements as part of their pre-registration training. The remote nature of some placement sites, shiftwork and the emotionally challenging nature of the workload has led to mental wellbeing issues in many students.

Aim: This project aimed to evaluate a novel 3D immersive virtual reality environment that supports mental wellbeing for NAHP students on clinical placement.

Evaluating lumateperone for its use in treating depressive episodes associated with bipolar I or II disorder in adults.

Introduction: Lumateperone is a novel antipsychotic medication that has recently received approval by the United States Food and Drug Administration for treatment of major depressive episodes of type I and II bipolar disorder. It is approved for use as monotherapy or as an adjunctive treatment to lithium or valproic acid.

Areas Covered: Clinical trials performed with lumateperone for bipolar disorder were reviewed.

A Rare Case of Amyand's Hernia.

A hernia is an abnormal protrusion of an organ or tissue from its containing cavity. The most common type of abdominal hernia is an inguinal hernia. When a hernia is non-reducible, it is termed an incarcerated hernia.

Catatonia Secondary to Depolarization Block.

Catatonia is a severe psychomotor disorder that is associated with a 60-fold increased risk of premature death. Its occurrence has been associated with multiple psychiatric diagnoses, the most common being type I bipolar disorder. Catatonia can be understood as a disorder of ion dysregulation with reduced clearance of intracellular sodium ions.

Perceptions on pregnancy and parenthood among program directors in pediatric dentistry.

Purpose: This cross-sectional study assessed the perceptions of pediatric dental residency program directors (PDs) regarding policies and attitudes on pregnancy and parenthood during residency training.

Methods: A 28-item electronic survey was administered to PDs of pediatric dental residencies in the United States. Statistical tests were performed.

Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.

The genetic and epigenetic architecture of clinical and subclinical hypothyroidism remains unclear. We investigated the impact of long noncoding RNA (LncRNA)-PAX8-AS1 and LAIR-2 genetic variants on the susceptibility to clinical and subclinical hypothyroidism, their influence on LncRNA-PAX8-AS1 and LAIR-2 expression and their potential as hypothyroid biomarkers. Hundred clinical hypothyroid patients, 110 subclinical hypothyroid patients, and 95 healthy controls were enrolled.

Treatment-Resistant Bipolar Depression: Therapeutic Trends, Challenges and Future Directions.

Introduction: Bipolar disorder (BD) is a chronic mental illness impacting 1-2% of the population worldwide and causing high rates of functional impairment. Patients with BD spend most of their time in depressive episodes and up to one-third of patients do not respond to adequate doses of medications. Although no consensus exists for definition of treatment-resistant bipolar depression (TRBD), failure of symptoms improvement despite an adequate trial of two therapeutic agents is a common theme of TRBD.

MicroCT evaluation for CAD/CAM occlusal veneer fit using two materials and three cement space settings.

This study was aimed to evaluate the fit of occlusal veneer restoration for two CAD/CAM materials with different cement space settings, using microCT scans. Sixty resin dies were made and divided into two groups (n=30) according to the materials, (I): Hybrid all-ceramic, and (II): zirconia-reinforced lithium silicate glass-ceramic. Each group was subdivided into three subgroups (n=10) according to the cement space parameters (30, 40, and 50 µm).

Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report.

Background: Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment.

Case Presentation: A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration.

Pharmacologic treatment and management of bipolar disorder in adolescents.

Introduction: The importance of the appropriate therapeutic interventions in children and adolescents with bipolar disorder (BD) cannot be overstated since treatment choices and their consequences may have effects into adulthood.

Areas Covered: Randomized clinical trials (RCTs) investigating treatment of mania, bipolar depression, and maintenance in adolescents with BD are reviewed. When RCTs are not available or are inadequate, naturalistic data or open studies are also reviewed.