Publications by authors named "Omar El-Taji"

Article Synopsis
  • Cardiovascular events are a major cause of death in men with advanced prostate cancer, and new treatments like androgen receptor signaling inhibitors (ARSI) may have unknown cardiovascular side effects.
  • The study aims to evaluate how the addition of ARSI affects the incidence of cardiovascular events in patients with locally advanced and metastatic prostate cancer.
  • A systematic review of 24 studies found that ARSI therapy significantly increases the risk of cardiovascular events, with a risk ratio indicating a higher incidence of both all-grade and severe cardiovascular issues.
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Article Synopsis
  • - Cystectomy is the preferred treatment for muscle-invasive bladder cancer, with robotic cystectomy gaining popularity due to benefits like quicker recovery, less blood loss, and reduced pain.
  • - The study reviewed the incidence of uretero-enteric strictures (UES) in different cystectomy techniques (open, robotic with extracorporeal diversion, and robotic with intracorporeal diversion) and found open surgery had the lowest stricture rate (9.6%).
  • - While robotic techniques showed higher UES rates, they may involve a learning curve, prompting a need for further research and Randomized Control Trials (RCTs) to compare the effectiveness and safety of surgical options.
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Urolithiasis is the most common cause of nonobstetric abdominal pain, resulting in 1.7 admissions per 1000 deliveries. Urolithiasis most commonly occurs in the second and third trimesters, with an incidence between 1:125 and 1:2000.

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Objectives: We sought to evaluate modern diagnostic and treatment options for urachal adenocarcinoma (UAC) and to provide clarity regarding the available options and their outcomes for this poorly understood yet damaging disease.

Material And Methods: We conducted a systematic literature search in PubMed and Medline focusing on updated management of UAC.

Results: Surgical intervention continues to be the mainstay of treatment for localized UAC.

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Article Synopsis
  • Current research indicates that axial skeleton magnetic resonance imaging (AS-MRI) is more effective than traditional bone scintigraphy (BS) for identifying bone metastases in high-risk prostate cancer patients, though BS remains common.
  • A study reviewing 503 high-risk prostate cancer patients showed that AS-MRI detected bone metastases in 17.5% of cases, significantly differing in PSA and clinical variables compared to those without metastases.
  • The study suggests that AS-MRI not only performs as well as or better than BS for detection, but also offers substantial cost savings for the healthcare system, with all patients receiving scans promptly within 14 days.
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Background: Pathological involvement of the seminal vesicle poses a treatment dilemma following robotic prostatectomy. Margin status plays an important role in deciding further management. A wide range of treatment options are available, including active monitoring, adjuvant radiotherapy, salvage radiotherapy, and occasionally androgen deprivation therapy.

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Background: Immunoglobulin G4-related disease remains a modern, relatively unknown field in the urological world. An increasing number of cases require urological input, often with invasive diagnostics and aggressive medical treatment first-line. Given this, we sought to evaluate modern radiological options of disease affecting the upper urinary tract, to provide clarity and reduce diagnostic burden and delay in this poorly understood yet potentially debilitating disease process.

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Robotic-assisted laparoscopic radical prostatectomy (RARP) has been traditionally performed at a pneumoperitoneum insufflation pressure of 12-15 mmHg. This meta-analysis and systematic review aims to assess the current evidence comparing lower to standard pressure pneumoperitoneum in RARP. Systematic searches of MEDLINE, COCHRANE, SCOPUS and EMBASE were performed to identify articles published up until November 2021 comparing lower pressure with standard pressure pneumoperitoneum in RARP.

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Introduction: We evaluate the data of 12,644 Radical Cystectomies in England (Open, Robotic and Laparoscopic) with trends in the adaption of techniques and post-operative complications.

Methods: This analysis utilised national Hospital Episode Statistics (HES) from NHS England.

Results: There was a statistically significant increase ( < .

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Background: Secondary neoplasms of the bladder account for 4.5% of all bladder neoplasms however there is limited literature reporting management and survival. This is the largest single centre series presented in current literature with long term oncological follow up.

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Background: Urosepsis is a recognized complication of transrectal ultrasound-guided prostate biopsy (TRUS-Bx). Pre-biopsy rectal swabs have been used to identify patients with microorganisms in the rectal flora resistant to the conventionally used empirical prophylaxis. The transperineal route of biopsy (TP-Bx) has a lower complication risk but comes at an increased cost.

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Objectives: To present our experience with the long-term preventive effect of immunotherapy with Uro-Vaxom® on recurrent urinary tract infections (UTI) in adult patients.

Materials And Methods: Retrospective analysis of 79 patients with recurrent UTI treated with Uro-Vaxom. Recurrent UTIs were defined as ≥ 2 infections in 6 months or ≥ 3 in 12 months.

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Objective: To evaluate the clinical and financial implications of a decade of prostate biopsies performed in the UK National Health Service (NHS) through the transrectal (TR) vs the transperineal (TP) route.

Methods: We conducted an evaluation of the TR vs the TP biopsy approach in the context of 28 days post-procedure complications and readmissions. A secondary evaluation of burden of expenditure in NHS hospitals over the entire decade (2008-2019) was conducted through examination of national Hospital Episode Statistics (HES) data.

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We report a case of prostatic lymphoma of the Walden-ström's macroglobulinemia subtype in a 64-year-old gentleman who underwent a robotic-assisted laparoscopic prostatectomy following lower urinary tract symptoms and high grade adenocarcinoma on transperineal prostate biopsy's. Histopathological and immunohistochemistry analysis at the time of surgery was consistent with a CD5-negative small B-cell lymphoma. To our knowledge this is the first reported prostatic lymphoma identified following robotic-assisted laparoscopic prostatectomy and the first documented case of lymphoplasmacytic lymphoma involving prostate.

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Organ preservation has been increasingly utilised in the management of muscle-invasive bladder cancer. Multiple bladder preservation options exist, although the approach of maximal TURBT performed along with chemoradiation is the most favoured. Phase III trials have shown superiority of chemoradiotherapy compared to radiotherapy alone.

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Ileal conduit urinary diversion is the gold standard treatment for urinary tract reconstruction following cystectomy. This procedure uses gastrointestinal segments for bladder augmentation, a technique that is often associated with significant complications. The substantial progression in the fields of tissue engineering and regenerative medicine over the previous two decades has resulted in the development of techniques that may lead to the construction of functional urinary bladder substitutes.

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