Multiple Myeloma Genomics - A Concise Review.

The aim of this review is to summarize the current knowledge of genomic information in multiple myeloma. Multiple myeloma is a genetically complex plasma cell neoplasm that evolves from pre-malignant stages following genomic evolution leading to the proliferation of malignant plasma cells and the production of monoclonal immunoglobulin. The outcomes of patients with myeloma have dramatically improved over the past decade with the introduction of novel agents.

[An unusual presentation of liver involvement in hereditary hemorrhagic telangiectasia biliary disease].

Hereditary Hemorrhagic Telangiectasia is a relatively common, under-recognized autosomal dominant disorder characterized by angiodysplastic lesions that affect multiple organs, like liver. This is a case of a 76 years old woman with history of pain in the lower third of right hemithorax, presence of tiny telangiectases in fingers, lips and tongue, in addition to pain on palpation of right hypochondrium; the initial abdominal ultrasound assessment showed biliary intrahepatic dilation. Patient meets The Diagnostic Criteria of Curacao for Hereditary Hemorrhagic Telangiectasia.