Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System.

Clavulanic acid (CLAV) is a non-antibiotic β-lactam that has been used since the late 1970s as a β-lactamase inhibitor in combination with amoxicillin, another ß-lactam with antibiotic activity. Its long-observed adverse reaction profile allows it to say that CLAV is a well-tolerated drug with mainly mild adverse reactions. Interestingly, in 2005, it was discovered that β-lactams enhance the astrocytic expression of GLT-1, a glutamate transporter essential for maintaining synaptic glutamate homeostasis involved in several pathologies of the central nervous system (CNS).

Study of Antispasmodic and Antidiarrheal Activities of (Mexican Tarragon) in Experimental Models and Its Mechanism of Action.

has been used in traditional medicine as a remedy to alleviate several gastrointestinal disorders that provoke stomachaches, abdominal cramps, and diarrhea. However, there is not enough scientific evidence that supports these effects. Therefore, the purpose of this study was to evaluate antispasmodic and antidiarrheal activities of aqueous extract of (AqExt-TL) as well as its mechanism of action in experimental models.

Potential pro-arrhythmic effects of pharmacotherapy against SARS-CoV-2.

The pandemic caused by the SARS-COV-2 or COVID-19 virus has been a global challenge given its high rate of transmission and lack of effective therapy or vaccine. This scenario has led to the use of various drugs that have demonstrated a potential effect against the virus in vitro. However, time has not been enough to properly evaluate their clinical effectiveness.

[Historical overview of acute infectious diarrhea in Mexico and future preventive strategies].

Objective: To analyze the epidemiological aspects of AID through Mexican history and the potential strategies to pre- vent AID in Mexican population.

Materials And Methods: A systematic review was performed exploring the key words, diarrhea, morbidity, mortality, Mexico, health promotion for the last 20 years (1978-2018).

Results: Over 8 600 articles were obtained; all of them were evaluated to consider those follow the aim of the present work.

Crossing event boundaries changes prospective perceptions of temporal length and proximity.

We conducted two experiments to investigate how crossing a single naturalistic event boundary impacted two different types of temporal estimation involving the same target duration - one where participants directly compared marked temporal durations and another where they judged the temporal proximity of stimuli. In Experiment 1, participants judged whether time intervals presented during movies of everyday events were shorter or longer than a previously encoded 5-s reference interval. We examined how the presence of a transition between events (event boundary) in the movie influenced people's judgments about the length of the comparison interval.

Exploratory studies of some Mexican medicinal plants: Cardiovascular effects in rats with and without hypertension.

Background: L., (L.) .

Endothelial function impairment in chronic venous insufficiency: effect of some cardiovascular protectant agents.

In segments of human varicose veins, endothelial function was assessed by measuring relaxation induced by acetylcholine in noradrenaline-precontracted preparations. In addition, concentration-response curves to acetylcholine were obtained before and after incubation with the arterial endothelium protectant agents captopril, losartan, troglitazone, pravastatin, or simvastatin. The antivaricose agent escin was also tested.

Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta.

The triterpene saponin escin is the active component of the extract of seeds of Aesculus hippocastanum used in the treatment of chronic venous insufficiency. Escin is also used experimentally to increase membrane permeability in isolated cells. Since endothelial dysfunction is postulated to be involved in venous insufficiency, the possible endothelium-protectant effect of escin was explored in rat aortic rings, a model widely used to study such effects with cardiovascular agents.

Antivasoconstrictor effect of the neuroprotective agent dexrazoxane in rat aorta.

Dexrazoxane is used clinically to reduce the cardiotoxicity of anthracycline cancer chemotherapeutic agents, acting by an iron-chelating antioxidant mechanism. In a study designed to explore the possible mechanism of the recently described neuroprotective effect of the drug in cerebral ischemia, its influence on vascular reactivity was determined in rat aortic rings. Dexrazoxane was found to be devoid of direct contractile or relaxant activity and to have no influence on responses to acetylcholine or histamine (relaxation), or to angiotensin or serotonin (contraction).