Publications by authors named "Omar Alejandro Zayas-Villanueva"
Purpose: Metastatic urothelial carcinoma (mUC) poses a challenge to health care systems, given its treatment complexity and mortality. We aimed to describe the characteristics, treatment patterns, and survival outcomes of Mexican patients with mUC.
Methods: A retrospective study was conducted across eight centers for adults with mUC from January /2001 to December 2021.
Identification of Germline Variants in Patients with Hereditary Cancer Syndromes in Northeast Mexico.
Genes (Basel)
January 2023
Hereditary cancer syndromes (HCS) are genetic diseases with an increased risk of developing cancer. This research describes the implementation of a cancer prevention model, genetic counseling, and germline variants testing in an oncologic center in Mexico. A total of 315 patients received genetic counseling, genetic testing was offered, and 205 individuals were tested for HCS.
View Article and Find Full Text PDFBilateral testicular germ cell tumors (BTGCT) occur in 1 to 4% of patients with testicular cancer and of these, 10-15% are synchronous. Overall, BTGCT represents less than 0.5% of all new cases of testicular cancer.
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- Hereditary breast and ovarian cancer (HBOC) syndrome is primarily linked to mutations in specific genes, with focus on the genetic variations in 3'UTR regions that affect microRNA binding and regulation.
- A study involving blood samples from 50 HBOC patients and 50 controls identified nine polymorphisms in these regions, with three variants significantly increasing the risk of developing HBOC.
- The findings suggest that these genetic variants can influence microRNA binding, highlighting their role in the development of HBOC.
Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case-control study.
BMC Cancer
July 2019
Background: Pathogenic variants (PVs) of BRCA genes entail a lifetime risk of developing breast cancer in 50-85% of carriers. Their prevalence in different populations has been previously reported. However, there is scarce information regarding the most common PVs of these genes in Latin-Americans.
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