STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.

Intraneuronal fibrillary tangles are a major hallmark of several neurodegenerative diseases including Alzheimer's disease. The major constituents of these hallmarks are hyper-phosphorylated tau. In this study we used a neuronal cellular model which over-expresses transcription factor STOX1A in combination with the longest human tau isoform to test the effect of STOX1A on tau phosphorylation.

Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor.

Background: In this study we investigated the involvement of the transcription factor STOX1A in the regulation of the cell cycle.

Methodology/principal Findings: We found that several major cell cycle regulatory genes were differentially expressed upon STOX1A stimulation and knockdown in the neuroblastoma cell line SH-SY5Y. This includes STOX1A dependent differential regulation of cyclin B1 expression, a cyclin which is known to regulate mitotic entry during the cell cycle.