Update on antimicrobial resistance in Somalia: Current status, challenges, opportunities, and future perspectives.

Antimicrobial resistance (AMR) is a critical global health challenge, and Somalia is no exception. This update examines the current status of AMR in Somalia, highlighting the prevalent patterns of resistance, contributing factors, and significant health impacts. Despite limited surveillance data, evidence suggests rising resistance to key antibiotics, exacerbated by inadequate healthcare infrastructure, overuse of antimicrobials, and lack of regulatory oversight.

Establishment of Reference Intervals for Common Renal and Liver Function Parameters in Healthy Adults in Mogadishu, Somalia: A Cross-Sectional Study.

Introduction: Reference intervals (RIs) are crucial for the accurate interpretating of laboratory test results in clinical settings, serving as benchmarks for evaluating individual health status. This study investigates the influence of sex and age on common liver function tests (LFTs) and renal function tests (RFTs) in healthy adults in Mogadishu, Somalia.

Methods: A community-based cross-sectional study was carried out from October 2022 to January 2023 on a randomly selected sample of 255 healthy participants from Mogadishu, Somalia.

Maternal Risk Factors Associated with Preterm Births among Pregnant Women in Mogadishu, Somalia.

Background: Premature birth impacts millions of newborns annually. Sixty percent of the world's preterm births occur in Sub-Saharan Africa and South Asia. Somalia's premature birth rates and maternal risk factors are poorly studied; hence, this study aims to identify maternal risk factors related to premature births in Mogadishu, Somalia.

Enhanced oral bioavailability and biodistribution of atractylodin encapsulated in PLGA nanoparticle in cholangiocarcinoma.

Atractylodes lancea (Thunb) DC. and its bioactive compound atractylodin (ATD), have been shown to exert promising anticancer activity against cholangiocarcinoma (CCA) both in vitro and in vivo. However, the clinical development of ATD could be hindered due to hydrophobicity and poor pharmacokinetic properties, and thus, the requirement of high dose administration and the risk of toxicity.

Antibiotic resistance pattern of Escherichia coli isolates from outpatients with urinary tract infections in Somalia.

Introduction: Several studies suggest increasing rates of antibiotic resistance among adult populations with Urinary tract infections (UTI). Escherichia coli (E. coli), is the predominant bacterium both in the community and in hospital environments causing uropathogenic infections.

Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review.

The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy.