Hyper-Immunoglobulin E (IgE) Syndrome: A Diagnostic Dilemma.

Hyper-immunoglobulin E (IgE) syndrome (HIES) is an immunodeficiency syndrome characterized by atopic dermatitis, recurrent skin abscesses, and sinopulmonary infections with elevated serum IgE. In addition, patients also present with other skeletal and non-immune symptoms. We present a six-year-old boy with severe atopic dermatitis, multiple food allergies, mild asthma, and recurrent sinopulmonary infections, who presented to the ER with left ankle pain, fever, and inability to bear weight.

Gianotti-Crosti Syndrome: A Benign Dermatosis.

Gianotti-Crosti syndrome (GCS) is a benign acral dermatitis commonly seen in children younger than five years of age with no gender predilection. Clinical features are often vague, including but not limited to fever, lymphadenopathy, and erythematous papular rash that commonly spares the trunk, palms, and soles of the feet. It is presumably underdiagnosed as most children presenting with a widespread papular rash are diagnosed with non-specific viral exanthem.