Endocrine disturbances in empty sella syndrome: case reports and review of literature.

Objective: To report 5 cases of empty sella syndrome (ESS) manifesting with various degrees of pituitary dysfunction.

Methods: We describe the initial manifestations in 5 patients with primary ESS and in previous cases of ESS reported in the English language literature.

Results: Review of our recent medical records identified 5 patients referred for evaluation of pituitary deficiencies in whom ESS was diagnosed.