Aryl (β,β',β″-Trifluoro)--butyl: A Candidate Motif for the Discovery of Bioactives.

The (β,β',β″-trifluoro)--butyl (TFTB) group has received very little attention in the literature. This work presents a direct synthesis of this group and explores its properties. The TFTB group arises when the methyl groups of a -butyl moiety are exchanged for fluoromethyl groups.