Gastroprotective mechanism of on ethanol-induced gastric ulcer in Wistar rats inflammatory, antioxidant, and H/K-ATPase inhibition-mediated pathways.

The increase in the incidence of gastric ulcer (GU) has posed major threat on public health. This research aimed to evaluate gastroprotective properties of the aqueous leaf extract of (AETT) in ethanol-induced gastric ulceration. GU was induced oral administration of single dose of 5 mLkg of 90% ethanol in rats and protection of 200 mgkg bw of AETT and 20 mgkg bw of omeprazole was investigated for 14 d oral treatment.

Telfairia occidentalis mitigates dextran sodium sulfate-induced ulcerative colitis in rats via suppression of oxidative stress, lipid peroxidation, and inflammation.

Ulcerative colitis (UC), a subcategory of inflammatory bowel diseases, affects more than 2 million people globally. This study sought to investigate the curative ability of aqueous leaf extract of Telfairia occidentalis (ATO) on dextran sodium sulfate (DSS)-mediated colitis in rats. UC was induced by 5% of DSS in drinking water, and the curative ability of ATO was assessed at 200 mg/kg by oral administration for 10 days.

Covid-19 treatment: Investigation on the phytochemical constituents of as potential Coronavirus-2 inhibitors.

The upsurge in the current cases of COVID-19 poses a major threat on human health and population all over the globe. The emergence of new infectious diseases and increase in frequency of drug resistant viruses demand effective and novel therapeutic agents. In this study, we used bioinformatics approach to investigate the possible inhibitory potentials of phytochemical constituents of towards coronavirus-2 major protease.

Neuroprotective mechanism of in a rat model of neurodegenerative diseases.

The global upsurge in the prevalence of neurodegenerative diseases in recent years has been associated with increase in toxic chemical exposure and release into the biosystem, having over 46.8 million people suffer dementia worldwide. This study focused on elucidating the neuroprotective mechanism of methanol leaf extract of (MLVA) in nitrobenzene-induced neurodegenerative disease in rats.

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants.

Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2.