Publications by authors named "Oluwaseun Ogedengbe"
Article Synopsis
- Researchers have created a detailed neuronal wiring diagram of the whole brain of a fruit fly (Drosophila melanogaster), mapping over 5 billion chemical synapses between more than 139,000 neurons, to better understand brain function.
- The study includes detailed annotations about various cell types, nerve pathways, and neurotransmitter identities, and the data is freely available for other researchers to use and explore.
- By analyzing synaptic pathways and connections, the project helps illustrate how neural structures relate to sensorimotor behaviors, paving the way for similar studies in other species.
Connections between neurons can be mapped by acquiring and analyzing electron microscopic (EM) brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative, yet inadequate for understanding brain function more globally. Here, we present the first neuronal wiring diagram of a whole adult brain, containing 5×10 chemical synapses between ~130,000 neurons reconstructed from a female .
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- Advances in automated imaging now allow for the mapping of entire brains, with projects needing significant time for data proofreading due to their size.
- FlyWire is introduced as an online platform that enables collaborative proofreading of neural circuits in fruit flies, utilizing 3D interactive tools for efficient editing from anywhere.
- The platform encourages community participation, enhances data accuracy, and promotes faster scientific discoveries, showcased through the analysis of mechanosensory neurons' connectome.