Publications by authors named "Oluwaseun Adeola"
Article Synopsis
- Left ventricular (LV) systolic dysfunction significantly increases the risk of heart failure and premature death, highlighting the need for effective screening methods.
- Researchers developed a deep learning algorithm that analyzes ECG images to detect LV systolic dysfunction and validated its accuracy using data from multiple hospitals and cohorts.
- The model showed strong performance, achieving high accuracy metrics (AUROC values above 0.90) across different clinical settings, demonstrating its potential as a reliable screening tool for heart dysfunction.
Substrate Mapping Alters Ventricular Tachycardia Inducibility.
Circ Arrhythm Electrophysiol
February 2023
Background: Initiation of ventricular tachycardia (VT) by programmed electrical stimulation (PES) has an important role to allow mapping and assess ablation end points. We hypothesized that substrate mapping may alter VT inducibility by mechanical bumping of critical sites.
Methods: Subjects with left ventricular scar-related VT that was inducible by PES who were undergoing ablation were included.
Article Synopsis
- The study investigates the safety and outcomes of subcutaneous ICD (S-ICD) implantation in patients with and without prior sternotomy.
- Results show no significant differences in sensing vector, lead placement, or defibrillation thresholds between the two groups, indicating similar effectiveness.
- The findings conclude that S-ICD implantation is safe for patients with prior sternotomy, exhibiting comparable rates of complications and inappropriate shocks as those without sternotomy.
Background: Residual peri-device leakage (PDL) is frequent after left atrial appendage occlusion (LAAO). Little is known about management strategies, procedural aspects and outcomes of interventional PDL closure.
Aims: The aim of this study was to assess the safety and feasibility of PDL closure after LAAO.
Article Synopsis
- Ventricular arrhythmias (VAs) can start from different spots in the right ventricle, and their unique ECG patterns help pinpoint their origin.
- Identifying the origin of these arrhythmias is important for planning treatments like ablation.
- The article reviews how VAs relate to structural heart diseases, highlighting specific ECG findings in both healthy and diseased right ventricles.
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid flow and hydrostatic pressure to regulate vascular function. Here, we show that the leucine-rich repeat-containing protein 8a, LRRC8A (SWELL1), is required for VRAC in human umbilical vein endothelial cells (HUVECs).
View Article and Find Full Text PDFPeriaortic Ventricular Tachycardias in Nonischemic Cardiomyopathy: Substrate and Electrocardiographic Correlations.
Circ Arrhythm Electrophysiol
February 2021
Background: Periaortic fibrotic ventricular tachycardia (VT) substrate is common in nonischemic cardiomyopathy (NICM), often intramural, and difficult to ablate. We sought to better characterize normal and abnormal periaortic voltage map parameters and NICM periaortic VTs.
Methods: In 15 patients without heart disease, the 5th percentile of endocardial voltage for increasing distance from the aortic valve ring was determined.
Background: Coronary artery calcium (CAC) is an indicator of atherosclerosis, and the CAC score is a useful noninvasive assessment of coronary artery disease.
Objective: To compare the risk of cardiovascular outcomes in patients with CAC > 0 versus CAC = 0 in asymptomatic and symptomatic population in patients without an established diagnosis of coronary artery disease.
Methods: A systematic search of electronic databases was conducted until January 2018 for any cohort study reporting cardiovascular events in patients with CAC > 0 compared with absence of CAC.
Background: Atrial fibrillation (AF) is associated with elevated risk for ischemic stroke and myocardial infarction (MI). The aim of the study is to assess the role of insulin use on the risk of stroke and MI in AF patients with diabetes.
Methods: We identified Medicare beneficiaries with new AF in 2011 to 2013.
Background: Directly observed treatment short-course (DOTS) strategy is an effective mode of treating TB. We aimed to study the cost effectiveness and patients' satisfaction with home based direct observation of treatment (DOT), an innovative approach to community-based DOT (CBDOT) and hospital based DOT (HBDOT).
Methods: A randomized controlled trial involving 150 newly diagnosed pulmonary TB patients in four TB clinics in Ile Ife , Nigeria, was done.
Objective: To analyze the GNRHR in patients with normosmic isolated hypogonadotropic hypogonadism (IHH) and constitutional delay of growth and puberty (CDGP).
Design: Molecular analysis and in vitro experiments correlated with phenotype.
Setting: Academic medical center.