silver nanoparticles modulate S/JAK/STAT and P13K/Akt/PTEN signalling pathways in the kidney of streptozotocin-induced diabetic rats.

Objectives: Diabetes nephropathy (DN) is one of the complications of diabetes mellitus (DM) marked by gradual progressive loss of renal function. SOCS/JAK/STAT and PI3K/Akt/PTEN signalling pathways are among the chain of interactions implicated in the onset, progression and pathology of DN. (bitter melon) is often used in folk medicine as therapy for DM due to its hypoglycemic properties.

Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annonaceae: in silico and in vivo studies.

Background: (Annonaceae) known as soursop is a common tropical plant species known for its numerous medicinal properties including obesity. The underlying mechanism of anti-obesity effect of was investigated. The fat mass and obesity associated protein (FTO) is a validated potential target for anti-obesity drugs.

Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes.

Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes.

Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats.

This study investigated the effect of saponins (20-100mg/kg) from Tithonia diversifolia leaf (STD) on the liver, kidney, heart, lipid profile and hematological parameters of normal rats. The results showed that STD (20-100mg/kg) though caused a slight increase in the liver, heart and kidney activity of ALT, AST, ALP and GGT (p<0.05), did not result in corresponding increase in the serum level of these enzymes.

Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes.

There has been a sharp rise in the global prevalence of diabetes, obesity, and their comorbid conditions within the last decade prompting significant research into possible causes and cure via therapeutic intervention and lifestyle adjustments. Here, the molecular bases of antidiabetic plants used in the prehistorical treatment of diabetes and obesity are reviewed with particular focus on saponin as the phytotherapeutic principle. Until recently, the phytotherapeutic potentials of saponins have been masked in the heterogeneity of phytochemicals co-extractable during traditional preparations.