Publications by authors named "Oluwakemi Anuoluwapo Rotimi"
Article Synopsis
- * By comparing gene expressions during prostate cancer regression and regrowth, researchers found that the protein soluble guanylate cyclase 1 subunit alpha plays a key role in enabling castration-resistant prostate cancer.
- * Virtual screening of 242 anti-prostate cancer phytochemicals identified (8'R)-neochrome and (8'S)-neochrome from spinach as promising drug candidates for inhibiting both normal and mutant forms of the soluble guanylate cyclase 1 protein.
Endocrine disrupting chemicals (EDCs) are xenobiotics which adversely modify the hormone system. The endocrine system is most vulnerable to assaults by endocrine disruptors during the prenatal and early development window, and effects may persist into adulthood and across generations. The prenatal stage is a period of vulnerability to environmental chemicals because the epigenome is usually reprogrammed during this period.
View Article and Find Full Text PDFThis study investigated the potential of stevioside to prevent oxidative DNA damage in the liver and kidney of type 2 diabetes mellitus (T2DM) using high fat-low streptozocin rat model. Rats were treated daily with 12.5, 25 and 50 mg/kg stevioside orally for 21 days.
View Article and Find Full Text PDFNaringin, a citrus-derived flavonoid with antihyperglycemic, antihyperlipidemic, and antioxidant properties, is reported to be a useful nutraceutical in the management of diabetes and its complications. This study investigated the mechanism of antiatherogenic properties of naringin in type 2 diabetes (T2DM) using high fat-low streptozocin rat model of T2DM. Rats were treated daily with 50, 100 and 200 mg/kg naringin orally for 21days.
View Article and Find Full Text PDFIn this study, alterations in lipid metabolism associated with acute aflatoxin B1 (AFB1) induced hepatotoxicity and gene expression changes underlying these effects were investigated. Rats were orally administered three doses (0.25 mg/kg, 0.
View Article and Find Full Text PDFHesperidin prevents lipopolysaccharide-induced endotoxicity in rats.
Immunopharmacol Immunotoxicol
October 2016
Context: Lipopolysaccharide (LPS) is a major trigger of septic shock resulting in multiple organ damage through excessive stimulation of the host's immune cells resulting in the release of cytokines. Previous studies have shown that hesperidin has several beneficial properties against inflammation and oxidative stress.
Objective: The influence of hesperidin on endotoxemia, endothelial dysfunction, inflammation, and oxidative stress was investigated using a murine model of sepsis.