Cellular and molecular mechanisms of aflatoxin B-mediated neurotoxicity: The therapeutic role of natural bioactive compounds.

Aflatoxin B (AFB), a dietary toxin from the mold Aspergillus species, is well acknowledged to elicit extra-hepatic toxicity in both animals and humans. The neurotoxicity of AFB has become a global public health concern. Contemporary research on how AFB enters the brain to elicit neuronal dysregulation leading to noxious neurological outcomes has increased greatly in recent years.

Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats.

Environmental pollution due to arsenic is associated with several adverse health effects including neurotoxicity in animals and humans. Selenium is a nutritionally essential trace metalloid well documented to elicit compelling pharmacological activities in vitro and in vivo. Report on the influence of selenium on arsenic-mediated behavioral derangement is lacking in literature.

Selenium abates reproductive dysfunction via attenuation of biometal accumulation, oxido-inflammatory stress and caspase-3 activation in male rats exposed to arsenic.

Frequent exposure to arsenic is well documented to impair reproductive function in humans and animals. Biological significance of inorganic selenium and organoselenium, diphenyl diselenide (DPDS), has been attributed to their pharmacological activities. However, their roles in arsenic-mediated reproductive toxicity is lacking in literature.