Publications by authors named "Olusola Y Dokun"
Article Synopsis
- The study investigates the expression of the protein PIWIL2 in human bladder cancer and finds that it is mainly expressed in testis tissue but not in bladder tissues or cancer cell lines.
- Researchers used quantitative RT-PCR to compare PIWIL2 expression across various bladder carcinoma cell lines and tissue samples, revealing that it was significantly lower in these compared to testis.
- While PIWIL2 shows potential as a tumor marker, the findings suggest it does not contribute to the development of human bladder cancer.
Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal differentiation markers. Expression of SNCG, S100A9 and LCN2 was also enhanced.
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