Antiparasitic Activities of Compounds Isolated from Strain Discovered in Northcentral Nigeria.

In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2).

Isolation and characterization of new phenolic siderophores with antimicrobial properties from sp. UIAU-6B.

Five new phenolic siderophores - were isolated from the organic extract of a culture broth in a modified SGG medium of sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A-C (-) and pseudomobactin A and B ( and ) isolated alongside two known compounds, pseudomonine () and salicylic acid (), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses.