Publications by authors named "Olusoji E Jagun"
Article Synopsis
- Nigeria has the highest global rate of peripartum cardiomyopathy, leading to a clinical trial that compared usual care with AI-guided screening for left ventricular systolic dysfunction (LVSD) in pregnant and postpartum women.
- The study involved 1,232 women, using digital stethoscopes and 12-lead electrocardiograms to identify LVSD, which was confirmed by echocardiography.
- Results showed that AI screening enhanced the detection rates of LVSD (4.1% vs. 2.0% for stethoscope AI; 3.4% vs. 2.0% for electrocardiogram AI), with no serious adverse events reported during the trial.
Most children acquire human immunodeficiency virus (HIV) infection through mother-to-child transmission (MTCT). The risk of MTCT of HIV is generally 15%-40% without prophylaxis. MTCT has been responsible for approximately 370,000 infant HIV infections worldwide, with Nigeria accounting for 30% of cases.
View Article and Find Full Text PDFBackground: Overt thyroid dysfunction is an accepted cause of female infertility. Its milder form, subclinical hypothyroidism have also been implicated as a contributing factor to disturbed reproductive function.
Objective: To determine the contribution of subclinical hypothyroidism (SCH) to the burden of infertility.
A case of thanatophoric dysplasia with sudden death at term is hereby presented. Thanatophoric dysplasia is an uncommon, lethal skeletal dysplasia which is associated with mutation in the extracellular region of fibroblast growth factor receptor 3 (FGFR3). It is an autosommal dominant condition that has sporadic occurrence and early ultrasound scan has not been of great benefit in its detection.
View Article and Find Full Text PDFObjective: To assess the effectiveness of hyoscine-N-butylbromide on the duration of the first stage of labor among nulliparous women.
Methods: A randomized double-blind placebo-controlled study among 126 nulliparous women admitted in the active phase of labor to a teaching hospital in Sagamu, Nigeria, from January to August 2018. Based on the inclusion criteria, women were recruited and randomized to the study or control group, and given intravenous hyoscine-N-butylbromide 20 mg (1 mL) or sterile water (1 mL), respectively, during the active phase.