Molecular Modeling Identification of Key Secondary Metabolites from as Promising Therapeutics Targeting Essential Measles Viral Proteins.

This study computationally screened three key compounds (vanillin (VAN), oxophoebine (OPB), and dihydrochalcone (DHC)) derived from (Guinea pepper), a medicinal plant with known antiviral activity, against key druggable measles virus (MV) proteins (fusion protein (FUP), haemagglutinin protein (HMG), and phosphoprotein (PSP)). Each molecular species was subjected to a 100 ns molecular dynamics (MD) simulation following docking, and a range of postdynamic parameters including free binding energy and pharmacokinetic properties were determined. The docking scores of the resulting OPB-FUP (-5.

A possible risk of environmental exposure to HEV in Ibadan, Oyo State, Nigeria.

Hepatitis E virus (HEV) infection is both a major public health concern and emerging global health concern, with a documented incidence of 20 million, 3.4 million clinical cases, 70,000 deaths, and 3,000 stillbirths. The aetiologic agent, HEV is a primarily enterally transmitted hepatotropic virus.

Effect of compression pressure, preservative, and storage with potassium chloride on the microbiological quality of tablets formulated with Terminalia randii Gum (Combretaceae).

Gums are used as binders in tablets and also as emulsion stabilisers, suspending agents and thickeners in syrups. The need for other natural gums apart from the conventional gums to be employed as binding agents in tablets formulation led to this study. A gum obtained from the incised trunk of Terminalia randii (Combretaceae) was evaluated for the effect of compression pressure, methyl paraben preservative and storage with potassium chloride, on the microbial load of tablets formulated with the gum.