Publications by authors named "Olumide Martins"
Article Synopsis
- * The study assesses bedaquiline's effectiveness, a drug approved for tuberculosis, in combination with imipenem against M. abscessus in various conditions, revealing that bedaquiline can be bactericidal against nutrient-starved bacteria while antagonizing imipenem in actively growing cultures.
- * Results indicate that the interaction between bedaquiline and imipenem depends on the growth conditions, suggesting that bedaquiline may enhance treatment outcomes against nutrient-starved or intracellular M. abscessus, despite previous observations of antagonism under
Tigecycline is used in multidrug regimens for salvage therapy of infections but is often poorly tolerated and has no oral formulation. Here, we report similar activity of two newly approved tetracycline analogs, omadacycline and eravacycline, against 28 drug-resistant clinical isolates of complex. Since omadacycline and eravacycline appear to be better tolerated than tigecycline and since omadacycline is also formulated for oral dosing, these tetracycline analogs may represent new treatment options for infections.
View Article and Find Full Text PDFPulmonary disease due to infection with complex (MABC) is notoriously difficult to treat, in large part due to the intrinsic resistance of MABC strains to most antibiotics, including β-lactams. MABC organisms express a broad-spectrum β-lactamase that is resistant to traditional β-lactam-based β-lactamase inhibitors but inhibited by a newer non-β-lactam-based β-lactamase inhibitor, avibactam. Consequently, the susceptibility of MABC members to some β-lactams is increased in the presence of avibactam.
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