Comparison of Mycobacterium tuberculosis drug susceptibility using solid and liquid culture in Nigeria.

Background: This study compares Mycobacterium tuberculosis culture isolation and drug sensitivity testing (DST) using solid (LJ) and liquid (BACTEC-MGIT-960) media in Nigeria.

Methods: This was a cross sectional survey of adults attending reference centres in Abuja, Ibadan and Nnewi with a new diagnosis of pulmonary tuberculosis (TB) or having failed the first-line TB treatment. Patients were requested to provide three sputum specimens for smear-microscopy and culture on LJ and BACTEC-MGIT-960.

A molecular epidemiological and genetic diversity study of tuberculosis in Ibadan, Nnewi and Abuja, Nigeria.

Background: Nigeria has the tenth highest burden of tuberculosis (TB) among the 22 TB high-burden countries in the world. This study describes the biodiversity and epidemiology of drug-susceptible and drug-resistant TB in Ibadan, Nnewi and Abuja, using 409 DNAs extracted from culture positive TB isolates.

Methodology/principal Findings: DNAs extracted from clinical isolates of Mycobacterium tuberculosis complex were studied by spoligotyping and 24 VNTR typing.

Drug prescription pattern for asthma among nigerian doctors in general practice: A cross-sectional survey.

Background: A wide range of medications are now available for the treatment of asthma and selection of the optimal treatment combination of agents is essential.

Objectives: This study was designed to evaluate a self-reported drug prescribing pattern for asthma among Nigerian doctors in general practice.

Methods: It was a cross-sectional survey conducted among general practitioners in six states of Nigeria.