A novel nor-megastigmane from the leaves of .

A novel nor-megastigmane, normegastigmane-5,9-epoxy-3,8-diol (), together with 10 known compounds of diverse classes including megastigmanes, sesquiterpenoids, and triterpenoids were isolated from the leaves of . The structure of was established by 1D and 2D NMR and HRESIMS data analysis. The known compounds were identified as 5,11-epoxy-3,9-megastigmanediol (), 7-megastigmene-3,6,9-triol (), 1,3-dihydroxypropan-2-yl stearate (), (1,5)-1,5-dimethyl-8-(propan-2-ylidene)cyclodeca-1,5-diene germacrene () 3,5-dihyroxy-6,7-megastigmadien-9-one (), squalene (), -amyrin (), -amyrone (), -amyrin eicosanoate (), and -sitosterol ().

Prevalence of haemoglobin A1c based dysglycaemia among adult community dwellers in selected states in Nigeria: a descriptive cross-sectional study.

Background: Type 2 diabetes mellitus (T2DM) is a disease of public health importance globally with an increasing burden of undiagnosed pre-diabetes and diabetes in low- and middle-income countries, Nigeria in particular. Pre-diabetes and diabetes are established risk factors for cardiovascular complications. However, data are scanty on the current prevalence of these conditions in Nigeria, based on haemoglobin A1c (HbA1c) diagnosis as recommended by the WHO in 2009.

COVID-19 Pandemic: A Case for Phytomedicines.

Coronavirus disease 2019 (COVID-19) is an infection caused by a newly discovered coronavirus which was identified in Wuhan, China. The race is on globally to repurpose drugs for COVID-19 and develop a safe and effective vaccine against the disease. There is an urgent need to search for effective remedies against COVID-19 from the rich and extensive flora of Africa and the world.

Knowledge and risk perception of e-cigarettes and hookah amongst youths in Lagos State, Nigeria: An exploratory study.

Introduction: Limited research exists describing young people's knowledge and risk perception of e-cigarettes and hookah in Nigeria. This qualitative study explored the knowledge and risk perception of e-cigarettes and hookah amongst young people in Lagos, Nigeria.

Methods: Participants (n = 20), aged 15-24 years who had used e-cigarettes or hookah at least once in the past 12 months, participated in three focus group (FG) discussions in January 2020.

Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from .

Phytochemical investigation of the leaves and bark of has led to the isolation of six new iridoids, subcordatanols I-V (- and ) and 1--methylcrescentin I (), along with two known analogues ( and ). Among them, subcordatanol I () is the first example of a 3,8-monoepoxy-iridoid featuring a caged 2-oxa-bicyclo[3.2.

Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa.

Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex.

Results From Nigeria's 2016 Report Card on Physical Activity for Children and Youth.

Background: The Nigerian Report card on Physical Activity (PA) in Children and Youth was first developed in 2013 to inform practice and policy on healthy living and prevention of noncommunicable diseases among Nigerian children and youth. This article summarizes the results of the 2016 report card and provides updated evidence on the current situation in Nigeria.

Methods: A comprehensive review of literature was undertaken by the Report Card Working Group.

Sub-acute and chronic toxicity profiles of Markhamia tomentosa ethanolic leaf extract in rats.

Ethnopharmacological Relevance: Markhamia tomentosa (Benth.) K. Schum Ex Engl.

Review of the Phytochemical and Pharmacological Studies of the Genus Markhamia.

Natural product compounds obtained from medicinal plants have been great contributions in the discovery of numerous clinically useful drugs. Markhamia species have been reportedly used by many cultures in human and veterinary traditional medicines. The five identified species of Markhamia, that is, Markhamia lutea, Markhamia obtusifolia, Markhamia stipulata, Markhamia tomentosa, and Markhamia zanzibarica have been the subject of chemical investigations that have led to the characterization of their secondary metabolites.

A new source of elemol rich essential oil and existence of multicellular oil glands in leaves of the Dioscorea species.

Dioscorea species is a very important food and drug plant. The tubers of the plant are extensively used in food and drug purposes owing to the presence of steroidal constituent's diosgenin in the tubers. In the present study, we report for the first time that the leaves of Dioscorea composita and Dioscorea floribunda grown under the field conditions exhibited the presence of multicellular oil glands on the epidermal layers of the plants using stereomicroscopy (SM) and scanning electron microscopy (SEM).

Antiproliferative and apoptosis inducing activity of Markhamia tomentosa leaf extract on HeLa cells.

Ethnopharmacological Relevance: Markhamia tomentosa (Benth) K. Schum ex. Engl.

Phenolic contents, antioxidant and antibacterial activities of Hymenocardia acida.

This study investigates the antioxidant and antibacterial activities of aqueous and methanolic extracts from Hymenocardia acida Tul. (Hymenocardiaceae). The inhibition values of the extracts and quercetin were found to be very close, with no significant differences at a concentration of 0.