A novel nor-megastigmane from the leaves of .

A novel nor-megastigmane, normegastigmane-5,9-epoxy-3,8-diol (), together with 10 known compounds of diverse classes including megastigmanes, sesquiterpenoids, and triterpenoids were isolated from the leaves of . The structure of was established by 1D and 2D NMR and HRESIMS data analysis. The known compounds were identified as 5,11-epoxy-3,9-megastigmanediol (), 7-megastigmene-3,6,9-triol (), 1,3-dihydroxypropan-2-yl stearate (), (1,5)-1,5-dimethyl-8-(propan-2-ylidene)cyclodeca-1,5-diene germacrene () 3,5-dihyroxy-6,7-megastigmadien-9-one (), squalene (), -amyrin (), -amyrone (), -amyrin eicosanoate (), and -sitosterol ().

Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from .

Phytochemical investigation of the leaves and bark of has led to the isolation of six new iridoids, subcordatanols I-V (- and ) and 1--methylcrescentin I (), along with two known analogues ( and ). Among them, subcordatanol I () is the first example of a 3,8-monoepoxy-iridoid featuring a caged 2-oxa-bicyclo[3.2.

Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa.

Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex.

Sub-acute and chronic toxicity profiles of Markhamia tomentosa ethanolic leaf extract in rats.

Ethnopharmacological Relevance: Markhamia tomentosa (Benth.) K. Schum Ex Engl.

Review of the Phytochemical and Pharmacological Studies of the Genus Markhamia.

Natural product compounds obtained from medicinal plants have been great contributions in the discovery of numerous clinically useful drugs. Markhamia species have been reportedly used by many cultures in human and veterinary traditional medicines. The five identified species of Markhamia, that is, Markhamia lutea, Markhamia obtusifolia, Markhamia stipulata, Markhamia tomentosa, and Markhamia zanzibarica have been the subject of chemical investigations that have led to the characterization of their secondary metabolites.

Antiproliferative and apoptosis inducing activity of Markhamia tomentosa leaf extract on HeLa cells.

Ethnopharmacological Relevance: Markhamia tomentosa (Benth) K. Schum ex. Engl.

Phenolic contents, antioxidant and antibacterial activities of Hymenocardia acida.

This study investigates the antioxidant and antibacterial activities of aqueous and methanolic extracts from Hymenocardia acida Tul. (Hymenocardiaceae). The inhibition values of the extracts and quercetin were found to be very close, with no significant differences at a concentration of 0.