Publications by authors named "Olugbo Y Obiabo"
Article Synopsis
- African ancestry populations have the highest stroke burden globally, yet the genetic factors contributing to stroke in these groups are not well understood, prompting the SIREN study in West Africa to investigate this.
- The study involved recruiting stroke patients and stroke-free controls to conduct a genome-wide association study (GWAS), leading to DNA analysis that identified significant SNPs near specific genes associated with stroke risk.
- Key findings highlighted protective genetic variants near AADACL2 and MIR5186 on chromosome 3, as well as other notable associations on chromosomes 5, 6, 12, 16, and 18, which could provide insights for future stroke risk assessment in these populations.
A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study.
J Stroke Cerebrovasc Dis
October 2021
Background: Stroke risk can be quantified using risk factors whose effect sizes vary by geography and race. No stroke risk assessment tool exists to estimate aggregate stroke risk for indigenous African.
Objectives: To develop Afrocentric risk-scoring models for stroke occurrence.
Background And Objectives: Limited access to medicines can impact negatively on outcomes in people with Parkinson's disease (PD). The study objectives were to determine the availability and assess the affordability of antiparkinsonian medications in pharmacies across Nigeria.
Methods: This was a cross-sectional nationwide study utilizing the World Health Organization/Health Action Initiative methodology.