Favorable therapeutic response of osteoporosis patients to treatment with intravenous zoledronate compared with oral alendronate.

Objectives: To evaluate the efficacy of orally-administered alendronate compared with intravenously-administered zoledronate.

Methods: This prospective study was carried out at Barts Health HNS Trust between April 2010 and March 2012. This study compares changes in bone mineral density (BMD) in 234 patients treated with 2 bisphosphonates: alendronate taken orally, and zoledronate administered intravenously.