Longitudinal Changes in Depressive Circuitry in Response to Neuromodulation Therapy.

Background: Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized.

Treatment of sleep disturbance in Alzheimer's dementia.

Objective: To review the evidence-base behind current treatment options for sleep disturbance in Alzheimer's dementia.

Design: A systematic review synthesized the qualitative and quantitative evidence on the treatment of sleep disturbance in Alzheimer's dementia. Studies with interventions targeting sleep disturbance in Alzheimer's dementia or other aspects of the neuropsychiatric symptoms, but which reported an effect on sleep, were included.