ANTIPLASMODIAL ACTIVITIES OF THE STEM BARK EXTRACT OF FORSBERG.

Background: The potential of stem bark as a safe antimalarial agent, and the identification of its antimalarial constituents was explored.

Materials And Methods: The air-dried stem bark was extracted with 70% ethanol, filtered and concentrated to obtain the extract (). The extract was successively partitioned to give -hexane (), dichloromethane (), ethyl acetate () -butanol () and aqueous () fractions respectively after determining the acute toxicity using Lorke's method.

Naringin Ameliorates HIV-1 Nucleoside Reverse Transcriptase Inhibitors- Induced Mitochondrial Toxicity.

Background: Mitochondrial reactive oxygen species (ROS) generation and defective oxidative phosphorylation (OXPHOS) have been proposed as possible mechanisms underlying the development of nucleoside reverse transcriptase inhibitors (NRTIs)-induced mitochondrial toxicities. Available options in managing these complications have, so far, produced controversial results, thus necessitating further research into newer agents with promise. Antioxidant and free-radical scavenging effects of naringin, a plant-derived flavonoid, have previously been demonstrated.

Prevention of Mother-to-Child Transmission of HIV/AIDS: Perception of Health Care Workers in Rural Areas of Oyo State.

Introduction. Proper implementation of prevention of mother-to-child transmission (PMTCT) services requires adequate knowledge and appropriate attitudes and practices on the part of the health care providers especially in rural areas where access to health care delivery is very limited in Oyo State. Materials and Methods.

Cerebellar toxoplasmosis in HIV/AIDS: a case report.

Background: Toxoplasma encephalitis is a common presentation of Toxoplasma gondii infection of the central nervous system in the late stage of human immunodeficiency viral (HIV) infection. The definitive diagnosis requires demonstration of toxoplasma in brain tissue. However, neuroradiologic demonstration (using Computed Tomography or Magnetic Resonance Imaging) of ring-enhanced multiple or single focal intracranial lesions in the presence of immunosuppression and prompt response to presumptive therapy are diagnostic in the absence of histological facilities.

Utility of predicted creatinine clearance using MDRD formula compared with other predictive formulas in Nigerian patients.

The new predictive formula generated during the study of Modification of Diet in Renal Disease (MDRD) to estimate the glomerular filtration rate in chronic kidney disease (CKD) patients was found to be superior to existing predictive formulas in all races including black Americans. We had previously published a study evaluating and comparing 5 predictive formulas and their applicability in Nigerian CKD patients and normal subjects. The existing data from this study were re-analyzed and the 5 previous formulas compared with the MDRD formula.

Diagnostic potentials of the activities of lectins with whole cells of three bacterial diarrheagenic agents: Aeromonas, Plesiomonas, Campylobacter.

The reactiviteisofstrains ofPlesionmona shigeloides, Campylobater jejuni, Campylobacter coli and Aeromonas species with some lectins namely Soyabean agglutinin (SBA), Ricinus communis agglutinin (RCA), Peanut agllutinin (PNA), Cancanavalin-A (Con-A), Lima bean agglutinin (LMA) and Abrin were investigated using the microtitre plate method. The results obtained show that all stains of A. hydrophila, A.