Erythrocyte membrane proteins in healthy Saudis and patients with hereditary spherocytosis and hereditary elliptocytosis.

Background: Little is known about hereditary spherocytosis (HS) and hereditary elliptocytosis (HE) in the native population of Saudi Arabia, even though these conditions are seemingly common. The purpose of this study was to ascertain the protein make-up of the red cell membrane in healthy Saudis and in patients with HS and HE.

Patients And Methods: Eighteen healthy Saudi subjects (13 males and 5 females), 11 patients with HS (6 males and 5 females) and 11 patients with HE (7 males and 4 females) were studied.

Reference range values of hematological parameters in Saudi healthy adults.

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Serum ferritin and other iron indices in adult Nigerians with chronic renal failure--review of management of anaemia.

Iron studies were carried out in twenty five adult male and female patients with chronic renal failure and thirty one "healthy" individuals as control. Results showed moderately severe anaemia in all the patients with a mean haemoglobin concentration of 7.4 mg/dl (range 6-9.

Serial evaluation of iron stores in pregnant Nigerians with hemoglobin SS or SC.

Iron status of nonpregnant and pregnant Nigerian patients with hemoglobin SS or SC were assessed using serial hematological parameters, measured by Coulter counter, and serial serum ferritin concentrations measured by radioimmunoassays. The median value of 393 micrograms/L (range, 175 to 900 micrograms/L) for serum ferritin in nonpregnant patients with Hb SS and SC was significantly higher than that found in nonpregnant patients with Hb AA (median, 89.8 micrograms/L; range, 13 to 250 micrograms/L).

Serial serum ferritin and other hematological parameters in normal Nigerian primigravidae.

Serial hematological indices using Coulter Counter and serum ferritin using radioimmunoassay techniques were determined in 20 healthy Nigerian primigravidae with hemoglobin genotype AA. PCV fell significantly (P less than 0.001) to a minimum value at 28 weeks that was 6% lower than the mean value at 8 weeks postpartum.

Serum ferritin values in Nigerian pregnant women.

Serum ferritin values have been studied in 28 indigenous Nigerian pregnant women during the second and third trimesters of pregnancy. The mean serum ferritin value in the second trimester is higher than that in the third trimester, however, the difference is not statistically significant. When our results are related to those of Fenton and co-workers in 1977 (Fenton V, Cavill I, Fisher J: Iron stores in pregnancy.

Evaluation of serum ferritin levels and other hematological parameters in a Nigerian population.

Hematological parameters, including serum ferritin, were estimated in a healthy Nigerian population and in patients with other clinical conditions. The hematological values fell within the reported range for healthy populations in other parts of the world. The mean serum ferritin value in the male population was 72.

Iron studies in patients with sickle cell disease.

The prevalence of iron deficiency anaemia during the first three decades of life was investigated in eighty-five patients with SS and SC haemoglobins. The parameters used were the haematocrit, serum iron, total iron binding capacity (TIBC), percentage saturation of transferrin and availability of iron in the bone marrow. The mean haematocrit values were similar throughout the three decades, but increased with age (r = 0.

Iron studies in pregnant and non-pregnant women with haemoglobin SS or SC disease.

Iron studies were performed in 22 pregnant and 18 non-pregnant women with haemoglobinopathies. Mean packed cell volume and mean haemoglobin concentration were significantly lower (p < 0.001) in haemoglobin SS patients than in haemoglobin SC patients, in both the pregnant and non-pregnant groups.

Genetically determined deficiency of glucose 6-phosphate dehydrogenase (type-A-) is expressed in the liver.

G6PD activity was determined in liver biopsy specimens from 31 patients (25 men and six women). The G6PD genotype of the patients was determined by carrying out on lysates of their red blood cells quantitative assays of the enzyme and starch-gel electrophoresis. In 21 subjects with normal G6PD activity in red cells, a relatively wide variation of G6PD activity was found in liver extracts.

Observation on haematological patterns in pulmonary tuberculosis in Nigerians.

Twenty-one cases of pulmonary tuberculosis seen in the last two years in the chest clinic of the University College Hospital, Ibadan were studied for their haematological patterns at diagnosis and three months after. One group was put on anti-tuberculosis drugs only while the other group was put on anti-tuberculosis drugs and oral iron. The haematological results after 3 months show a significant rise in packed cell volume (PCV) less than 0.

Iron deficiency in pregnant women in Ibarapa District of Western Nigeria.

Ninety-nine pregnant women with anaemia (haematocrit less than 0.30) were detected by antenatal screening in Ibarapa District. Studies on 23 anaemic women and 17 non-anaemic women from the same clinic on the same day showed that eight out of 23 anaemic women had a transferrin saturation of less than 15%.

Non-Hodgkin's lymphoma in Ibadan, Nigeria.

One hundred patients with non-Hodgkin's lymphoma were admitted to the University College Hospital in Ibadan, Nigeria between 1960 and 1975. Their cases have been analyzed with respect to clinical findings, histological classification, and response to therapy. There was a preponderance of males over females (2:1) and the majority of the patients (87 percent) had reticulum cell sarcoma.

The treatment of iron-deficiency anaemia with a new intramuscular iron preparation (Ferastral).

The treatment of iron-deficiency anaemia in pregnancy with a new intramuscular iron preparation, iron-poly (sorbitol-gluconic acid) complex (Ferastral), has been assessed and compared with oral iron therapy. Sixty-one of the eighty-four patients studied, many of whom had mild to moderate degree of anaemia were treated with Ferastral. The results were satisfactory, the mean increase of haematocrit at the sixth post treatment week was 28.

Clinical trial of Ferastral in iron-deficient, non-pregnant patients in Ibadan, Nigeria.

Fifteen patients with proven iron-deficiency anaemia treated with intramuscular injections of Ferastral, iron-poly (sorbitol-gluconic acid) complex, have been studied. Fourteen showed a satisfactory rise in haematocrit. No local or systemic complications were observed.

The therapy of Hodgkin's disease in Nigeria: a five year study.

Between 1970 and 1974 seventy patients suffering from Hodgkin's disease were admitted and treated in University College Hospital (UCH), Ibadan, out of which fifty (71.4%) had well documented chemotherapy. Standard combination chemotherapy of COPP/MOPP i.

Monoclonal gammopathy (Waldenström's macroglobulinaemia) producing specific red cell antibody.

Two cases of Waldenström's macroglobulinaemia have been seen at University College Hospital, Ibadan in the last four years, Case 1 was a 30-year-old soldier who presented with splenomegaly and anaemia, was treated with chlorambucil, and had a complete remission sustained for over two years. Case 2 was a 58-year-old retired civil servant who presented with very severe anaemia and also splenomegaly, and died within three weeks of admission. Both patients had most of the typical features of Waldenström's disease, including retinal changes and serum IgM levels of 4200 and 5500 mg/dl respectively.

Hereditary spherocytosis in Nigerians.

Five cases of hereditary spherocytosis in Nigerians are discussed. The clinical presentation and haematological abnormalities are similar to those described in other parts of the world. In one patient family studies were negative.