Effects of glutathione and potassium iodide on silver diamine fluoride application on remineralisation and colour change in dentine caries of primary teeth: an in vitro study.

Purpose: The aim of this study is to compare the effect of GSH (reduced glutathione) and KI (potassium iodide) on SDF (silver diamine fluoride) discolouration and dentine remineralisation.

Methods: Sixteen primary molars were utilised, yielding 4 dentine specimens each. Three specimens per tooth were allocated: one as a control and the others to experimental groups.

Is total thyroidectomy more difficult in Hashimoto's thyroiditis?

Aim: Hashimoto's thyroiditis (HT) is accepted as a difficult thyroidectomy for surgeons in practice, but there is not enough data in the literature to support this. The aim of this study was to evaluate whether HT belongs to difficult thyroidectomy class or not.

Material And Methods: 614 patients who undergoing total thyroidectomy were evaluated.

Dicentric Recombinant Chromosome 18 due to Maternal Paracentric Inversion Analyzed by Array CGH.

Introduction: Chromosomal abnormalities are mostly found in 0.5-0.8% of live-born infants with developmental and morphological defects.

Shared Biological Pathways and Processes in Patients with Intellectual Disability: A Multicenter Study.

Background: Although the underlying genetic causes of intellectual disability (ID) continue to be rapidly identified, the biological pathways and processes that could be targets for a potential molecular therapy are not yet known. This study aimed to identify ID-related shared pathways and processes utilizing enrichment analyses.

Methods: In this multicenter study, causative genes of patients with ID were used as input for Disease Ontology (DO), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes enrichment analysis.

Evaluation of disease burden, patient journey, unmet diagnosis and treatment needs of patients with HIP and knee osteoarthritis in Turkey: A study through Delphi Methodology.

Objective: To get information-driven insights from expert physicians regarding multiple aspects of the patient journey in knee and hip OA and establish a consensus for future studies and decision tree models in Turkey.

Design: 157 questions were asked in total during this three-round modified Delphi-method panel to 10 physical medicine and rehabilitation specialists (2 have rheumatology and 3 have algology subspeciality), one orthopaedic surgeon and one algology specialist from anaesthesia specialty background. A consensus was achieved when 80% of the panel members agreed with an item.

Early onset disease, anarthria, areflexia, and dystonia can be the distinctive features of SPG64, a very rare form of hereditary spastic paraplegias.

Hereditary spastic paraplegias (HSP) are a group of inherited, neurodegenerative disorders characterized by progressive gait impairment, lower extremity spasticity and increased patellar reflexes. More than 80 types of HSP have been defined to date. In complicated forms, lower limb spasticity and gait impairment is accompanied by an additional neurological finding.

[Pneumococcal infections and protection with vaccination in adult chronic lung diseases].

Pneumococcal infections are an important cause of mortality and morbidity in Chronic Lung Diseases. However, exacerbations, which make the treatment of diseases very difficult, and corticosteroids used during treatment carry a great risk of pneumococcal infection and adversely affect the treatment. The most rational way to reduce the negative impact of pneumococcal infections on the clinical and economic burden of Chronic Lung Diseases is vaccination of the risky population.

Genotype-phenotype correlation in seven motor neuron disease families with novel ALS2 mutations.

Autosomal-recessive mutations in the Alsin Rho guanine nucleotide exchange factor (ALS2) gene may cause specific subtypes of childhood-onset progressive neurodegenerative motor neuron diseases (MND). These diseases can manifest with a clinical continuum from infantile ascending hereditary spastic paraplegia (IAHSP) to juvenile-onset forms with or without lower motor neuron involvement, the juvenile primary lateral sclerosis (JPLS) and the juvenile amyotrophic lateral sclerosis (JALS). We report 11 patients from seven unrelated Turkish and Yemeni families with clinical signs of IAHSP or JPLS.

The factors of pancreatic fistula development in patients who underwent classical pancreaticoduodenectomy.

Aim: Pancreatic fistula (PF) and anastomotic leakage are significant complications of the pancreaticoduodenectomy (PD). The PF is considered as the root cause of other major complications of PD. The aim of the study was to investigate the risk factors underlying PF that occurred after PD and the effects of the PF on postoperative morbidity.

Omentopexy versus falciformopexy for peptic ulcer perforation.

Background: Open or laparoscopic Graham's omentopexy is frequently used in the treatment of peptic ulcer perforation (PUP). The technical difficulty of applying the omental plug, especially in patients with previous omentum resection, has led to the use of falciform ligament for the PUP, and some studies have reported that PUP may even be a more advantageous technique than omentopexy. Here, in this study, we aimed to compare the retrospective results of patients who underwent falciformopexy or omentopexy for PUP.

Microtensile Bond Strength and Failure Modes of Flowable Composites on Primary Dentin with Application of Different Adhesive Strategies.

Background: Resin composite is an option for the restoration of primary teeth, and new materials with simplified procedures are increasingly being suggested.

Aims: This study aims to evaluate the microtensile bond strengths and fracture modes of flowable composites on primary dentin with application of different adhesive strategies.

Materials And Methods: Sixty extracted noncaries primary molars were abraded from buccal surfaces to expose dentin surface.

Analysis of centrosome and DNA damage response in PLK4 associated Seckel syndrome.

Microcephalic primordial dwarfism (MPD) is a group of autosomal recessive inherited single-gene disorders with intrauterine and postnatal global growth failure. Seckel syndrome is the most common form of the MPD. Ten genes are known with Seckel syndrome.

Feasibility of endoscopic submandibular ganglion neurectomy for drooling.

We performed endoscopic transoral neurectomy of the submandibular and sublingual glands to treat drooling. We bilaterally operated two adult cases with treatment-resistant drooling. In these patients, conventional treatment had failed.

Maturogenesis of an Early Erupted Immature Permanent Tooth: A Case Report With 7-Year Follow-Up.

The main objective of treatment of an undeveloped tooth (immature) is to provide vital pulp therapy to allow continued development of root dentin. A case report is presented that demonstrates the use of calcium hydroxide (CaOH₂) as an indirect pulp-copping material for the purpose of continued maturogenesis of an early-erupted permanent tooth with severe mobility and almost-begun root formation. Seven-year radiographic and clinical follow-up demonstrated a vital pulp and physiologic root development without any endodontic failure clinically or radiographicaly.

A practical scoring system to predict mortality in patients with perforated peptic ulcer.

Introduction: The mortality rate of perforated peptic ulcer is still high particularly for aged patients and all the existing scoring systems to predict mortality are complicated or based on history taking which is not always reliable for elderly patients. This study's aim was to develop an easy and applicable scoring system to predict mortality based on hospital admission data.

Methods: Total 227 patients operated for perforated peptic ulcer in two centers were included.

Novel splice-site and missense mutations in the ALDH1A3 gene underlying autosomal recessive anophthalmia/microphthalmia.

Aim: This study aimed to identify the underlying genetic defect responsible for anophthalmia/microphthalmia.

Methods: In total, two Turkish families with a total of nine affected individuals were included in the study. Affymetrix 250 K single nucleotide polymorphism genotyping and homozygosity mapping were used to identify the localisation of the genetic defect in question.

Morphological analysis of the resin-dentin interface in cavities prepared with Er,Cr:YSGG laser or bur in primary teeth.

Objective: The purpose of this study was to analyze the resin-dentin interface in cavities prepared with laser or bur in primary teeth.

Background Data: Erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser was expected to be an alternative cavity preparation method, enhancing surface alterations and producing morphological changes.

Methods: Twenty extracted primary molar teeth were divided to four groups according to one of four cavity preparation and pretreatment regimens: Er,Cr:YSGG laser (G1), Er,Cr:YSGG laser+acid-etching (G2), bur (G3), and bur+acid-etching (G4).

Polycystic liver transplant: a case report.

A liver from a donor with brain death due to a ruptured cerebral aneurysm was transplanted. The liver had multiple bilobar simple cysts; the largest was less than 3 cm in diameter. The noncystic liver volume was greater than 50%, and the liver had neither fibrosis nor venous congestion.

Comparison of laser fluorescence devices for detection of caries in primary teeth.

The aim of this in vivo study was to evaluate the performance of fluorescence-based devices in detecting occlusal caries lesions in primary molars compared with conventional methods. Two examiners assessed 44 occlusal surfaces of first and second primary molars in 20 patients using two fluorescence devices: DIAGNOdent (LF) and DIAGNOdent pen (LFpen). Teeth were also assessed by visual examination and bitewing radiograph.

Treatment of pilonidal disease by combination of pit excision and phenol application.

Aim: To examine the results of our minimal invasive treatment for pilonidal disease.

Methods: Total 83 patients treated by pit excision and consecutive phenol applications on an outpatient setting. All procedures were performed under local anesthesia, without any preoperative testing, colon cleansing, prophylactic antibiotics or sedation.

Nanoleakage in primary teeth prepared by laser irradiation or bur.

The aim of this in vitro study was to analyze hybrid layer and nanoleakage of composite resin restorations in cavities prepared by either Er,Cr:YSGG laser or bur, followed by acid etching in primary teeth. Ten extracted primary molar teeth were randomly allocated into two groups consisting of ten cavities according to surface treatment regimen: Er,Cr:YSGG laser + acid etching(group 1) and bur + acid etching(group 2). Restorations of all samples were completed.

Clinicopathological characteristics of hepatocellular carcinoma in Turkey.

Background: Hepatocellular carcinoma (HCC), the main malignant tumor of the liver, is very common and highly lethal. The aim of this study was to determine its clinicopathologic characteristics and risk factors in Turkey.

Materials And Methods: In this study, patients who were diagnosed as suffering from HCC in the period between August 2004 and December 2011 were evaluated retrospectively.

Bond strength of adhesive systems to mineral trioxide aggregate with different time intervals.

Introduction: The aim of this study was to compare the shear bond strengths of various adhesive systems to white mineral trioxide aggregate (WMTA) with different time intervals.

Methods: Two hundred cylindrical acrylic blocks with a hole (4-mm diameter and 2-mm height) were prepared. The holes were filled with WMTA, and the specimens were allocated into 5 groups.