Publications by authors named "Olli Arola"
Article Synopsis
- Inhaled xenon combined with hypothermia was tested on comatose patients who survived out-of-hospital cardiac arrest (OHCA) to see if it could protect gray matter in the brain.
- A study of 110 patients found that those who received inhaled xenon and temperature management showed less reduction in brain gray matter volume, especially in areas like the amygdala and temporal gyrus, compared to those who received only temperature management.
- The results suggest that inhaled xenon can help preserve brain structure in this patient group, highlighting its potential therapeutic benefits.
Article Synopsis
- This study investigates the effects of inhaled xenon on metabolic outcomes in out-of-hospital cardiac arrest survivors receiving targeted temperature management.
- Blood samples showed that increased lactate and decreased branched-chain amino acids (BCAAs) were associated with higher mortality rates at 24 and 72 hours post-arrest.
- The findings suggest that high levels of lactate and alanine, along with low BCAAs and small HDL cholesterol, are linked to negative outcomes, while inhaled xenon did not significantly impact the metabolic profile of patients.
Background: Ventricular extrasystoles (VESs) are common and often harmless in a healthy heart, but they can significantly affect the quality of life. If changes in lifestyle and antiarrhythmic medication are not enough, invasive and often curative catheter ablation can be considered. Better understanding of the conformation of VESs with a 12-lead ECG, as well as their precise localization, have increased their treatment with catheter ablation.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the effectiveness of brain imaging techniques (DTI, 1H-MRS), serum NSE, and motor scores in predicting poor neurological outcomes in comatose patients after out-of-hospital cardiac arrest.
- Results showed that the predictive accuracy of these methods was not significantly better than the motor score alone, although combining data from multiple methods slightly improved accuracy.
- Ultimately, while there is a small benefit in using advanced imaging together with motor scores and seizures for prediction, the complexity and cost make routine use of DTI/MRS in clinical settings unnecessary.
Introduction: Inner ear decompression sickness (IEDCS) is a condition from which only a minority of patients recover completely, the majority ending up with mild to moderate residual symptoms. IEDCS has been reported after deep technical dives using mixed breathing gases, and moderate recreational dives with compressed air as the breathing gas. Considering this and the high proportion of technical diving in Finland, a comparison between IEDCS cases resulting from technical and recreational dives is warranted.
View Article and Find Full Text PDFUnlabelled: This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest.
Design: A randomized two-group single-blinded phase 2 clinical drug trial.
Setting: A multipurpose ICU in two university hospitals.
Purpose: Catheter ablation for atrial fibrillation (AF) is a standard procedure for maintaining sinus rhythm. The aim of this study was to evaluate treatment success and its predictors and to provide quality control data on complications and redo operations in a centre with an initially a low but currently high annual volume.
Methods: Data on patients (n = 1,253) treated with catheter ablation for AF in Tays Heart Hospital between January 2010 and May 2018 was evaluated (n = 1178 ablation-naïve patients and n = 1514 AF ablations).
Background: The current biomarkers for diagnosis and monitoring of injured and diseased skeletal muscles, such as creatine kinase (CK), have limited tissue specificity and incapability to differentiate between pathological and physiological changes. Thus, new biomarkers with improved diagnostic accuracy are needed. Our aim was to develop and validate a novel assay for skeletal troponin I (skTnI), and to assess its clinical performance in patients with idiopathic inflammatory myopathies (IIM).
View Article and Find Full Text PDFIntroduction: This is the first published study on decompression illness (DCI) and its treatment in Finland. Diving conditions are demanding, as even in the summer the water temperature below 20 meters' sea/fresh water (msw/mfw) is 4-10°C. Technical diving has become more popular over the years, so the emphasis of this study was to describe DCI in technical divers and compare it with non-technical recreational divers.
View Article and Find Full Text PDFBackground: Late radiation cystitis is an adverse effect of cancer treatment with radiotherapy in the pelvic region. Symptoms of late radiation cystitis can be assessed with the Expanded Prostate Index Composite Score (EPIC). Previous reports indicate that hyperbaric oxygen therapy reduces symptoms from late radiation cystitis, but the evidence is predominantly based on non-randomised and retrospective studies.
View Article and Find Full Text PDFAim: Cardiac arrest is not a common complication of sepsis, although sepsis has been recognized as one condition behind cardiac arrest. Our aim was to evaluate the prevalence of sepsis among patients with inhospital cardiac arrest (IHCA), and to determine if sepsis is associated with inferior outcome after IHCA.
Methods: All consecutive emergency team dispatches in Turku University Hospital in 2011 to 2014 (n = 607) were retrospectively reviewed to identify the patients undergoing cardiopulmonary resuscitation (CPR) for IHCA (n = 301).
Background: The authors previously reported that inhaled xenon combined with hypothermia attenuates brain white matter injury in comatose survivors of out-of-hospital cardiac arrest (OHCA).
Objectives: A pre-defined secondary objective was to assess the effect of inhaled xenon on myocardial ischemic damage in the same study population.
Methods: A total of 110 comatose patients who had experienced OHCA from a cardiac cause were randomized to receive either inhaled xenon (40% end-tidal concentration) combined with hypothermia (33°C) for 24 h (n = 55; xenon group) or hypothermia treatment alone (n = 55; control group).
Importance: Evidence from preclinical models indicates that xenon gas can prevent the development of cerebral damage after acute global hypoxic-ischemic brain injury but, thus far, these putative neuroprotective properties have not been reported in human studies.
Objective: To determine the effect of inhaled xenon on ischemic white matter damage assessed with magnetic resonance imaging (MRI).
Design, Setting, And Participants: A randomized single-blind phase 2 clinical drug trial conducted between August 2009 and March 2015 at 2 multipurpose intensive care units in Finland.
Objectives: Preclinical studies reveal the neuroprotective properties of xenon, especially when combined with hypothermia. The purpose of this study was to investigate the feasibility and cardiac safety of inhaled xenon treatment combined with therapeutic hypothermia in out-of-hospital cardiac arrest patients.
Design: An open controlled and randomized single-centre clinical drug trial (clinicaltrials.