Publications by authors named "Olivier de Lacharriere"
Background: Hyperpigmented spots develop earlier and with a higher incidence in Asian individuals compared with Europeans. Although actinic lentigines (AL) are very common, the biological events underlying their formation remain ill-defined.
Objective: AL from Japanese volunteers were characterized through morphological and gene expression analyses.
Skin complexion and pigmentary disorders in facial skin of 1204 women in 4 Indian cities.
Indian J Dermatol Venereol Leprol
May 2015
Background: The color of Indian skin shows great diversity and pigmentary disorders are a major concern of Indian women. Despite great variations in climate, diet, and social parameters within India, studies of the range of skin types have been rather scarce.
Aims: This study was aimed at characterizing the color of Indian skin in various geographical locations, its characteristics in terms of overall skin complexion and pigmentary disorders, and the impact of age on these features.
In atopic dermatitis (AD), the skin barrier is disturbed, and the expression of calcium-dependent S100 proteins and the calcium gradient is also altered in the epidermis. The calmodulin-like skin protein (CLSP), which is expressed in the differentiated epidermis, is believed to modulate the function of calcium-dependent proteins involved in barrier formation and is significantly increased in the epidermis of psoriatic patients. We, therefore, investigated the CLSP level in skin biopsies taken from patients with acute exacerbated and non-exacerbated AD as well as from healthy control subjects.
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- - The study investigates how different ethnicities (Asian, African, and Caucasian) experience sensitivity to capsaicin, a compound found in chili peppers that can cause a burning sensation.
- - Conducted on 144 women, the research involved applying varying concentrations of capsaicin to one side of their faces to measure their detection thresholds, revealing minor differences in sensitivity among the ethnic groups.
- - Overall, results indicated that Asian women had higher sensitivity to capsaicin than Caucasians but lower sensitivity than Africans, with the differences being relatively minor across all groups.
Article Synopsis
- About 50% of women consider their skin sensitive, but this perception lacks a clear physiological basis, prompting researchers to explore the neural response to skin irritants through fMRI.
- Participants were categorized based on their self-reported skin sensitivity and underwent fMRI scans while experiencing discomfort from lactic acid applications to measure brain activation.
- Results showed that those with sensitive skin exhibited greater brain activation in specific areas, suggesting a distinct neurophysiological pattern linked to their perception of skin sensitivity.
The calcitonin gene-related peptide from the skin of the frog Phyllomedusa bicolor (pbCGRP) is a 37-residue neuropeptide that differs from human alpha CGRP (halphaCGRP) at 16 positions. The affinities of the C-terminal fragments of pbCGRP and halphaCGRP were evaluated in SK-N-MC cells: pbCGRP(8-37) (K(i)=0.2nM) and pbCGRP(27-37) (K(i)=95nM) were, respectively, 3 times and 20 times more potent than the human fragments halphaCGRP(8-37) and halphaCGRP(27-37).
View Article and Find Full Text PDFObjectives: Dehydroepiandrosterone (DHEA) is a steroid hormone involved in physiological aging. When administered by oral route, it has been shown to positively affect skin condition on aged people. The purpose of this pilot study was to observe the in vivo effects on skin aging of topical DHEA (1%).
View Article and Find Full Text PDFIron deficiency has been suspected to represent one of the possible causes of excessive hair loss in women. The aim of our study was to assess this relationship in a very large population of 5110 women aged between 35 and 60 years. Hair loss was evaluated using a standardized questionnaire sent to all volunteers.
View Article and Find Full Text PDFBackground: The architectural frameworks of the skin microcirculation are rather complex and change continuously with aging. But these changes are yet poorly documented in vivo.
Objectives: Using non-invasive methods belonging to the field of biometrology, the study aimed to investigate quantitatively the changes of the cutaneous microvasculature in different anatomic sites with age.
Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe the age-related changes of the skin topography and skin microcirculation.
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- This study evaluated a new test measuring skin sensitivity using capsaicin on 150 healthy adult women to establish detection thresholds.
- Subjects applied various capsaicin concentrations on their skin and reported sensations, enabling classification into different sensitivity levels.
- Results indicated two distinct groups: those with low and high sensitivity, with lower thresholds aligning with self-reported sensitive skin, suggesting the test's potential for cosmetic applications.
Background: A study of the scalp in a large cohort of volunteers with androgenetic alopecia using macrophotographs showed the presence of peripilar signs (PPS) around the hair ostia.
Objective: The aim of the present study was to establish the histopathological features related to PPS.
Design: Prospective clinicopathological study.