Effects of adenosine monophosphate used in combination with L-arginine on female rabbit corpus cavernosum tissue.

Introduction: Sexual dysfunction is significantly more prevalent in women than in men. However, to date, no satisfactory oral treatment is yet available.

Aim: The aim of this study was to study the effects of adenosine monophosphate (AMP) alone or its combination with L-Arginine on the relaxation of the female rabbit corpus cavernosum.

Characteristic features of in vivo skin microvascular reactivity in CADASIL.

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is caused by mutations in the Notch3 receptor expressed at the surface of vascular smooth muscle cells. The functional consequences of the disease at the peripheral microcirculation level are incompletely elucidated. In this study, we aimed to assess, in vivo, the endothelium-dependent and independent vasodilation of the skin microvasculature in CADASIL patients.